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Klion D - instructions for use, side effects, analogues, reviews, price

Klion-D 100 is an antiviral, antifungal drug for external use.

The main feature is the combinatorial chemical interaction of two active substances - metronidazole and miconazole. It is a fully synthetic remedy that treats diseases associated with an infectious lesion of the genital system.

On this page you will find all the information about Klion D: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Klion D. candles. Do you want to leave your opinion? Please write in the comments.

Release form and composition

  • Active ingredients: 100 mg of metronidazole and 100 mg of miconazole nitrate in each vaginal tablet.
  • Excipients: sodium lauryl sulfate, anhydrous colloidal silica, magnesium stearate, povidone, sodium bicarbonate, tartaric acid, sodium A-carboxymethyl starch, crospovidone, hypromellose, lactose monohydrate.

Pharmacological effect

Antifungal action, which has a drug Klion-D, possibly due to the content of two powerful components - miconazole and metronidazole.

The first active substance of vaginal tablets fights the fungus itself, by acting on the cell membrane of microorganisms. They begin to weaken and die soon. Miconazole relieves irritating itching, which are accompanied by all the diseases of a fungal nature. This component of the drug is poorly absorbed into the blood, if you enter it into the vagina. Its presence is not detected either in the blood or in waste products. The advantage of miconazole is that even after 8 hours, about 90% of the substance is in the environment of the vagina, providing all this time antifungal effects.

Metronidazole Klion-D 100 acts as an antibacterial and antiprotozoal agent. It penetrates the DNA of microbes and blocks the process of cell division. With the help of this substance, the pathogen stops growth and reproduction.

Indications for use

What are they curing for? Klion D is prescribed to eliminate infectious and inflammatory diseases, the cause of which is associated with the negative effect of a number of anaerobic bacteria. These diseases include osteomyelitis, sepsis, brain abscesses, peritonitis, abscesses of the lungs and small pelvis, meningitis, endometritis and gas gangrene.

  • Also used as a preventive measure to get rid of infectious complications (caused by anaerobic streptococci and bacteroids) after surgery in the abdominal cavity and pelvic organs.

In some cases, candles are used to treat local vaginal infections.

Contraindications

Klion D should not be taken in the following cases:

  1. You can not use Klion D during pregnancy (in the first trimester) and during lactation,
  2. In diseases of the blood, leukopenia, problems with motor coordination, liver failure, disorders of the central nervous system,
  3. Additional consultation is required for patients with diabetes mellitus and microcirculation failure,
  4. If the patient has an increased sensitivity to some components of this remedy.

Use during pregnancy and lactation

Klion-D 100 is contraindicated for use in the first trimester of pregnancy. The use of the drug in the II and III trimesters is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus.

Metronidazole is excreted in breast milk. During breastfeeding, the use of Klion-D 100 is contraindicated. If necessary, the use of the drug during lactation should stop breastfeeding.

Instructions for use

The instructions for use indicate that the Klion-d candles are applied intravaginally, after having previously moistened the tablet with water.

Usually the course of treatment Klion-d 100 lasts 10 days with simultaneous oral administration of drugs containing metronidazole (Klion-d).

In the period of application of candles Klion-d is recommended to refrain from sexual contact. It is also recommended that simultaneous treatment of oral partner Klion-d for oral administration, regardless of whether the disease manifests itself.

Instructions for tablets

Klion-d in the form of tablets take:

  1. With lamblioza - during the week 2 times a day, 2 tablets,
  2. When amebiasis - three times a day, 2 tablets for 7-10 days,
  3. With trichomoniasis - one twice a day, morning and evening, for 10 days. Perhaps the use of 8 tablets as a single dose in the evening.

Side effects

The drug is well tolerated by patients, but in some cases the following adverse reactions develop:

  1. Discoloration of urine,
  2. Strengthening vaginal discharge,
  3. Changes in the clinical picture of blood,
  4. From the side of the central nervous system - dizziness and headaches,
  5. Allergic reactions - a rash on the skin, urticaria, in rare cases, the development of angioedema,
  6. On the part of the digestive tract - in rare cases, a violation of the chair, changes in taste, dry mouth, nausea, abdominal pain, increased gas generation,
  7. Local manifestations - discomfort, itching, burning, swelling, redness of the mucous membranes, foreign body sensation in the vagina.

Overdose

Data on overdose with intravaginal use of metronidazole are missing. However, when used concurrently with metronidazole, systemic effects may develop.

Symptoms of metronidazole overdose: nausea, vomiting, abdominal pain, diarrhea, generalized itching, metallic taste in the mouth, movement disorders (ataxia), dizziness, paresthesia, convulsions, peripheral neuropathy, leukopenia, darkening of urine.

Treatment: in case of accidental ingestion of a large number of vaginal tablets Klion-D 100, if necessary, gastric lavage, the introduction of activated carbon, hemodialysis can be performed. Metronidazole does not have a specific antidote.

Symptoms of miconazole overdose have not been identified.

special instructions

  1. Metronidazole can immobilize treponemas, which leads to a false-positive TPI test (Nelson's test).
  2. During the period of use of the drug should not drink alcohol (the risk of disulfiram-like reactions).
  3. When using Klion-D 100, a slight leukopenia can be observed, therefore it is advisable to monitor the blood picture (the number of leukocytes) at the beginning and at the end of therapy.
  4. During the period of use of the drug is recommended to refrain from sexual contact. The simultaneous treatment of sexual partners is recommended.

If side effects occur in the central nervous system, one should refrain from driving and working with potentially dangerous machinery.

Drug interaction

Klion-D 100 can give negative reactions with other drugs, or vice versa, to enhance the effectiveness. Do not combine the drug with the following formulations:

  1. Phenobarbital leads to a decrease in the concentration of metronidazole.
  2. Cimetidine can provoke toxicity, as it worsens metabolism.
  3. Muscle relaxants are non-depolarizing category.
  4. Absolute antagonism with ethanol.
  5. The content of lithium components increases, which requires an adjustment of the dosage of such medicines.

The drug is compatible with antibiotics of different groups, including para-aminobenzenesulfonamides. You should refrain from intimacy during the course.

We picked up some reviews of women about Klion D's candles:

  1. Helena . Prescribed to drink 10 days. On the second day, terrible nausea and weakness began, an unpleasant taste in the mouth. Now 6 days of admission weakness and nausea does not pass and does not increase, the taste remains. I will never agree to this medicine again, I will ask for injections or imported analogues.
  2. Valentine. Often suffered from thrush. I always treated her myself, but this time something went wrong. She went to the gynecologist for an appointment and he prescribed vaginal tablets Klion-D 100 for me. Already in the morning there was no itching and burning. After three days of use of the drug stopped excretion. After the course with the drug Klion, I have not been thinking about thrush for 6 months.
  3. Helena . Klion causes a terrible itch - worse than from the thrush itself! I put a pill into the vagina before bedtime, so I can't fall asleep, the whole thing burns, it burns, it tingles and itches, so that I even in I-no has got to look for explanations for this. Fearfully. Suddenly, after that, some side effects will be? The author of the article about Klion writes that a negative attitude towards this drug in people with emotional perception. I would look at him, as he himself would have been unemotional about the fact that everything inside is tweaking and burning! And you can’t sleep from that.
  4. Nastya. In vain listened to friends who advised different ways of treating thrush. There is no result, I'm sick of getting sick and went to a gynecologist. The doctor prescribed Klion-D - candles that look like unusual tablets. The price is quite normal, wet them and set. Cool: the other evening stopped itching, after 3 days it became much better.

Analogs of Klion D are the following drugs:

  • Bacimex
  • Deflamon,
  • Metrovagin,
  • Metrogil,
  • Metroxan,
  • Metrolaker,
  • Metron,
  • Metronidazole,
  • Metronidal,
  • Metroseptol,
  • Orvagil,
  • Rozamet,
  • Rozex,
  • Syptrogil,
  • Tricho pin,
  • Trichobrol,
  • Trichopol,
  • Trichosept
  • Flagyl,
  • Efloran.

Before using analogues consult your doctor.

Dosage, release forms and composition of Klion D

Currently, the drug Klion D is available only in one dosage form - vaginal tablets. Klion D in the form of candles (suppositories) is not performed. The correct name of the drug is Klion D, however, the following variants can be used in everyday life - “Klion D tablets” and “Klion D 100”. The drug is manufactured by the Hungarian pharmaceutical corporation GEDEON RICHTER, Plc. In the sale of Klion D comes in packs of 10 tablets.

Tablets Klion D are painted in white or almost white color, have an oval, biconvex shape and a pointed end. On one side of the tablets there is an extruded engraving "100". The size of the tablet is 14 X 24 mm.

Each tablet Klion D as an active ingredient contains 100 mg metronidazole and 100 mg miconazole . Metronidazole has antibacterial and antiprotozoal effects, and miconazole - antifungal.

As auxiliary components of the tablet Klion D contain the following chemical compounds:

  • Sodium lauryl sulfate,
  • Colloidal silicon dioxide,
  • Magnesium stearate,
  • Povidone,
  • Sodium bicarbonate,
  • Wine acid,
  • Sodium carboxymethyl starch,
  • Crospovidone,
  • Hypromellose,
  • Lactose monohydrate.

Klion-D - testimony

The drug with the release form (vaginal tablets) is used for the local treatment of gynecological infections provoked by bacteria and fungi. Efficiency is defined by 2 effective elements in the composition. Active show:

  • metronidazole is an antibacterial, antiprotozoal substance that kills bacteria,
  • miconazole - antifungal component.

Klion-D - candles, made as almond-shaped tablets, which are moistened with water before use, are inserted into the vagina. Doctors recommend doing such procedures at night. What does Klion-D treat? First of all - gynecological infections. Indications for use Klion-D is candidiasis or thrush, gardnerellosis. Features has the use of medication for vaginitis:

  • if the disease is caused by trichomonads, except for candles, metronidazole is used inside,
  • with candidal infections, imbalance of microflora, Klion suppositories are put twice a day.

Absorption, distribution and elimination of Klion D

Klion D tablets are used for intravaginal administration, and therefore have a local effect, destroying pathogenic microorganisms directly into the woman's vagina. However, after the introduction of the tablet into the vagina, metronidazole contained in it as one of the active substances is able to be absorbed into the systemic circulation. At the same time, the maximum concentration of metronidazole in the blood is reached 6 to 12 hours after the injection of the Klion D tablet into the vagina. Moreover, the blood concentration is 50% of that which is recorded when taking 100 mg of metronidazole orally. Due to its good absorbability into the bloodstream, metronidazole from Klion D tablets, administered intravaginally, penetrates into breast milk, and through the placenta to the fetus, and into the structures of the spinal cord and brain.

The part of metronidazole in the blood is 60–80% excreted by the kidneys in the form of chemical metabolites that stain urine in a reddish or brown color. The remaining 20 - 40% of metronidazole, sucked into the bloodstream, excreted through the intestine.

Miconazole, unlike metronidazole, is practically not absorbed into the systemic circulation. Therefore, miconazole with intravaginal administration is not detected either in the blood or in the urine. 8 hours after the introduction of the Klion D tablet, 90% of miconazole is still present in the woman's vagina, exerting a powerful destructive effect on the fungi of the genus Candida.

Klion D - therapeutic effects and scope

Klion D has an antibacterial, antifungal and antiprotozoal effect, which is provided by two active ingredients - metronidazole and miconazole.

Metronidazole provides a detrimental effect on the simplest (antiprotozoal effect) and bacterial (antibacterial action) microorganisms. And miconazole provides antifungal effects.

Metronidazole inhibits the reduction of nitro groups inside the cells of the protozoa and bacteria. As a result, an unrestored nitro group suppresses microbial DNA synthesis, combining with certain regions of nucleic acids. The absence of DNA synthesis leads to the impossibility of reproduction of microorganisms and, accordingly, their death.

Miconazole inhibits the synthesis of one of the main lipid components of the fungal membrane, ergosterol. Due to the absence of ergosterol, the membrane of the fungal cell becomes loose and excessively permeable to water and salts, which come from the surrounding space into the cell matrix in an excessive amount. Excess water and salt provoke a disturbance of the normal balance inside the cells, which leads to the death of fungi. Miconazole has a selective effect, destroying only fungi, and without disturbing the composition of the normal microflora and acidity of the vagina.

Klion D is active against the following pathogens:

  • Fungi of the genus Candida (mainly Candida albicans),
  • Trichomonas vaginalis (Trichomonas vaginalis),
  • Vaginal amoeba (Entamoeba histolytica),
  • Gardnerella (Gardnerella vaginalis),
  • Guardia (Giardia lamblia),
  • Bacteroids - Bacteroides spp. (B. fragilis, B. ovatus, B. distasonis, B. thetaiotaomicron, B. vulgatus),
  • Fuzobakterii (Fusobacterium spp.),
  • Wylonellas (Veillonella spp.),
  • Prevotella - Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens),
  • Clostridium (Clostridium spp.),
  • Eubacteria (Eubacterium spp.,
  • Peptococci (Peptococcus spp.),
  • Peptostreptokokki (Peptostreptococcus spp.).

Due to the characteristics of the clinical spectrum of Klion D tablets, they are mainly used for the treatment of trichomoniasis, candidiasis and other infectious and inflammatory diseases of the vagina, provoked by conditionally pathogenic and pathogenic microflora (for example, gardneurlosis, clostridiase, amebiasis).

Klion D with trichomoniasis

Klion D for trichomoniasis (trichomonas vulvitis) must be inserted deep into the vagina, one tablet wetted with water once a day. It is recommended to introduce a pill in the evening, just before going to bed. Duration of treatment is 10 days. For maximum effectiveness of treatment of trichomonas vulvitis (coleitis), simultaneously with vaginal administration of Klion D, it is necessary to take orally one tablet of Klion or Metronidazole twice a day (morning and evening) during or after meals, for 10 days as well. Metronidazole tablets must be swallowed whole, without chewing. If a 10-day course of treatment with Clion D did not lead to the cure of trichomoniasis, then it can be extended for another 10 days.

When treating trichomoniasis in a woman, simultaneous therapy of the sexual partner with oral preparations of metronidazole is recommended.

Courses for treating trichomoniasis using Klion D can be repeated as necessary.

Klion D with thrush

Klion D for thrush is inserted deep into the vagina once a day for 10 days. Every day, you must enter one pre-moistened tablet. The optimal time for the introduction of the tablet Klion D is the evening, right before going to bed.

If necessary, the treatment of candidiasis Clion D can be repeated as many times as necessary. However, with repeated inefficiencies of Klion D, it is recommended to conduct a vaginal discharge test for sensitivity to antimycotics, which will help determine which particular antifungal drug the Candida fungus, which caused candidiasis in this particular case, is sensitive to.

Klion D during pregnancy

В первом триместре беременности (до 12-ой недели гестации включительно) Клион Д противопоказан к применению, поскольку входящий в его состав метронидазол способен всасываться в системный кровоток и проникать через плаценту к плоду. In the second and third trimesters of pregnancy (from the 13th to the 40th week of gestation), Klion D can be used only if the expected benefit exceeds the potential risks to the fetus.

According to experimental studies of metronidazole conducted on pregnant rats and mice, no negative effect of the drug on the fetus was detected even with the administration of five times the dose to females. When intraperitoneal (intraperitoneal) administration to rats of a human dose of metroniadazole, an increase in toxic effects on fetus was recorded. However, with the introduction of the same dose of metronidazole in the form of tablets, no toxic effect on the fetus was detected. Similar studies on pregnant women for obvious ethical reasons have not been conducted. However, according to studies made on mathematical models built on the results of experiments on animals, no increase in adverse effects on the fetus was observed when using metronidazole at any stage of pregnancy, including in the first trimester. That is why metronidazole can not be used during pregnancy as widely as you want. Klion D tablets can be used when all possible risks have been evaluated and it has been concluded that the benefits of the drug for a pregnant woman will be higher compared to hypothetical risks for the fetus.

Since metronidazole from vaginal tablets Klion D penetrates into the systemic circulation, and from there into breast milk, you should not use the drug while breastfeeding. It is better to stop breastfeeding at the time of use of Klion D tablets and resume it after completing the course of therapy. You can resume breastfeeding after 1 - 2 days after using the last tablet of Klion D.

Special instructions for use of Klion D

During treatment with Klion D, no treponema test can be performed, as metronidazole provokes false-positive Nelson test results (TPI test).

When using Klion D, there may be a decrease in the total number of leukocytes below the norm (leukopenia), therefore during the whole course of treatment it is recommended to regularly take a complete blood count.

Klion D can provoke various side effects from the central nervous system, therefore during treatment with this drug it is recommended to abandon any activity that requires high concentration of attention and high speed of psychomotor reactions, for example, driving a car, conveyor, etc.

Interaction with other drugs

Klion D can be used in combination with antibiotics and sulfa drugs administered intravenously, intramuscularly or through the mouth.

You cannot use Klion D in conjunction with Disulfiram, as this can cause confusion. It is also not recommended to use Klion D in combination with muscle relaxant (muscle relaxant) vecuronium bromide.

Klion D enhances the effect of indirect anticoagulants (for example, Warfarin, Dikumarin, Thrombostop, etc.) as a result of which the combined use of these drugs may result in a pronounced increase in prothrombin time, which requires correction (decrease) in the dose of anticoagulant.

Drugs capable of enhancing the processes of microsomal oxidation in the liver (for example, Phenobarbital, Phenytoin, alcohol, etc.) accelerate the elimination of metronidazole from the body, which reduces its effectiveness. Therefore, the combined use of Klion D with drugs that enhance microsomal oxidation in the liver is not recommended.

Cimetidine reduces the rate of elimination of metronidazole, which can lead to increased severity of side effects.

Klion D increases the plasma concentration of lithium, so for the time of treatment with metronidazole, it is necessary to reduce the dosage of lithium preparations or stop taking them.

Klion D - reviews

Reviews of Klion D tablets are quite different - there are positive, almost enthusiastic, and negative. On average, the ratio of positive to negative reviews is 75% and 25%.

Women who have left positive reviews believe that Klion D tablets perfectly cure thrush. The advantages of the drug women include high efficiency, relatively low cost, the number and convenient form of tablets, as well as quick action. The disadvantages of Klion D, according to women, are burning and itching that occurs after the introduction of the pill into the vagina, a large range of contraindications and side effects. In addition, many women note that the tablets are inconvenient to use for a number of reasons: firstly, they are fragile and break down strongly when removing their packaging, as a result of which it is necessary to introduce it in parts, secondly, the surface of the tablet is rough, which creates discomfort in the process of moving it around the vagina.

However, these disadvantages of Klion D tablets are women who give positive feedback about the drug, are considered quite tolerant, because ultimately the treatment is effective. Women are well aware that the inflamed mucous membrane of the vagina reacts with itching and burning sensation to the action of the drug, and for the cure it is necessary to endure these unpleasant sensations.

Negative reviews in most cases were left by women and girls to whom itching and burning after the introduction of Klion D seemed unbearable, impossible, and therefore they felt that the drug was "bad." In such negative reviews clearly visible only emotional perception of reality immature psyche, which does not fit the phenomenon from an analytical position, and only focuses on the discomfort, not to say a word about the effectiveness of the drug in their particular case. The girls indicate that they cannot tolerate "such agony" for the treatment of thrush, considering that the drug should not only be effective, but also very pleasant. In reality, this almost never happens, so you should not rely on emotional feedback, which reflects the discomfort arising in the course of treatment, and not a word is said about the effectiveness of the drug.

There is another small part of the negative reviews, due to the fact that in these specific cases, Klion D was not effective. In such reviews, women usually describe that the drug did not help cure thrush or trichomoniasis, so they leave negative feedback, however, stipulating that Klion D might not have approached them, and it would be a great help to others.

Klion D - how to buy?

Klion D can be purchased at any regular pharmacy or online store. According to the prescription, Klion D tablets are sold by prescription, but in practice, pharmacists almost always dispense the drug without it.

When buying Klion D, you should pay attention to the shelf life of the drug, which is 5 years from the date of production. It is recommended to store tablets in a place protected from moisture and light at air temperature within 15–30 o C. If Klion D storage conditions do not correspond to the required, then the drug may partially or completely lose its therapeutic properties, and then its use will be ineffective.

Klion-D candles - instructions for use

The main active ingredients of the drug are metronidazole, miconazole. Manufacturers add to the composition of the candles additional substances:

  • hydroxypropyl methylcellulose 2910,
  • sodium bicarbonate,
  • sodium lauryl sulfate,
  • povidone,
  • magnesium stearate,
  • colloidal anhydrous silicon,
  • lactose monohydrate,
  • sodium carboxymethyl starch type A,
  • Crospovidone,
  • tartaric acid.

In order not to get complications, side effects, it is necessary to study the annotation to the candles of Klion D. The instructions stipulate:

  • contraindications for use
  • the inadmissibility of drinking with alcohol,
  • exclusion of use during the breastfeeding period due to the ingestion of the drug in milk,
  • compatibility of the drug with antibiotics,
  • increased action of anticoagulants,
  • when used with ethanol, the appearance of mental disorders,
  • careful use when driving motor vehicles.

According to the instructions, the use of vaginal suppositories is recommended once, overnight. They are pre-moistened with water to facilitate deep insertion into the vagina. In the package 10 candles, which is enough for a course of treatment. The drug Klion-D acts quickly, eliminating unpleasant symptoms in a short time. It is important to note that when using candles it is required:

  • conduct simultaneous treatment of a partner
  • refrain from working with complex aggregates,
  • exclude sexual intercourse at this time,
  • to control the level of white blood cells due to lower values ​​during treatment.

Klion-D during pregnancy

The waiting period of the baby is often accompanied by a drop in immunity, the occurrence of candidiasis, which can cause harm to the child. Klion-D during pregnancy is unacceptable to use in the early stages, when the fetus is the formation of organs and systems. Eliminated independent use of drugs in this period. With great care, in case of serious problems, gynecologists prescribe Klion-D vaginal tablets in the last weeks of pregnancy. Before birth, candles are used to clean the birth canal so as not to infect a newborn.

Klion-D - side effects

Doctors prescribing the drug should provide that there is an individual intolerance to individual components. The instructions stipulate contraindications for use:

  • epilepsy,
  • breastfeeding period
  • blood diseases
  • leukopenia,
  • lack of coordination of movements,
  • 1 trimester of pregnancy
  • liver failure,
  • children up to 12 years
  • organic disorders of the central nervous system.

The patient should be warned by the doctor about the side effects of Klion-D. The likelihood of such symptoms is high:

  • mucosal irritation,
  • burning, itching in the female genitals,
  • headaches,
  • white discharge with mucus,
  • skin rash,
  • diarrhea,
  • nausea,
  • dizziness,
  • constipation,
  • abdominal cramps
  • vomiting
  • irritation, burning of the penis partner,
  • dark urine staining.

Candles Klion-D - cheaper counterparts

The drug is considered very effective with an affordable price. In the pharmaceutical market you can find similar, differing in cost in both directions, but no less effective. Analogs of Klion-D:

  • Metromikon-Neo,
  • Gelangin,
  • Metronidazole + Miconazole,
  • Vagiferon,
  • Metrovagin,
  • Wagisept
  • Neo-Penotran,
  • Orvagil,
  • Neo-Penotran Forte,
  • Efloran.

pharmachologic effect

Klion-D 100 is a broad-spectrum drug. The main active ingredient is metronidazole, which is a derivative of nitro-5-imidazole. The mechanism of action of this substance is to restore the 5-nitro group in the anaerobic microorganism and protozoa. This leads to the death of microorganisms due to the interaction of the reconstituted 5-nitro group of metronidazole with the microbial cell DNA.

Klion-D 100 is active against a large number of microorganisms, such as Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, Gardnerella vaginalis, and it is also active against anaerobic bacteria - Bacteroides spp. Veillonella spp., Fusobacterium spp., Prevotella spp.

Effective use of this drug for the treatment of diseases caused by certain gram-positive microorganisms, such as Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp. Facultative anaerobes and aerobic microorganisms are insensitive to Klion-d 100, but in the treatment of mixed aerobic-anaerobic infections, its use is recommended.

Klion-D 100 is very effective against fungi, including dermatophytes and yeast fungi. Candles for intravaginal use effectively fight Candida albicans. Miconazole is able to inhibit ergosterol biosynthesis in fungal cells, which leads to their death. At the same time, the normal microflora and the pH of the vagina during treatment with this drug do not change.

250 mg tablets

The drug is taken orally during or after a meal (squeezed milk), without chewing.

Giardiasis: adults are prescribed 500 mg 2 times a day for 5-7 days.

Children over 8 years old - 500 mg per day (in 2 doses), at the age of 5 to 8 years old - 375 mg per day, at the age of 3 years and older - 250 mg per day, the daily dose should be divided into 2 doses, the course of treatment - 5 days. The dose of the drug may be 15 mg / kg per day in 3 doses for 5 days.

Treatment of chronic alcoholism: prescribed at a dose of 500 mg per day for a period of up to 6 (not more) months.

For the prevention of infectious complications: 750-1500 mg per day in 3 doses for 3-4 days before surgery, or once a dose of 1 g in the first day after surgery. 1-2 days after surgery (when oral administration is already allowed) - 750 mg per day for 7 days.

Trichomoniasis: adults are prescribed 250 mg 2 times a day for 16 days or 400 mg 2 times a day for 5-8 days. Women need to additionally assign Klion in the form of vaginal suppositories or pills. If necessary, you can repeat the treatment or increase the dose to 0.75-1 g per day. Between courses, you should take a break of 3-4 weeks with repeated laboratory tests.

An alternative treatment regimen is the appointment of 2 g once a patient and his sexual partner.

For children aged 2-5 years, the drug is prescribed at a dose of 250 mg per day, at the age of 5-10 years - 250-375 mg per day, over 10 years - 500 mg per day. The daily dose should be divided into 2 doses. The course of treatment is 10 days.

Liver abscess: the maximum daily dose is 2.5 g in 1 or 2-3 doses for 3-5 days, in combination with antibiotics (tetracyclines) and as part of complex therapy.

Children from 3 years old - 1/4 dose of an adult, at the age of 3-7 years - 1/3 doses of an adult, at the age of 7-10 years - 1/2 dose of an adult.

  • Asymptomatic amebiasis (if a cyst is detected): Adults are prescribed in a daily dose of 1-1.5 g (500 mg 2-3 times a day) for 5-7 days.
  • Ulcerative stomatitis: adults are prescribed 500 mg 2 times a day for 3-5 days. Children in this case, the drug is not shown.
  • Chronic amebiasis: 1.5 g per day in 3 divided doses for 5-10 days.
  • For eradication of Helicobacter pylori: 500 mg 3 times a day for 7 days (as part of combination therapy, for example, in combination with amoxicillin 2.25 g per day).
  • Acute amebic dysentery: 2.25 g per day in 3 divided doses until symptoms cease.
  • Treatment of anaerobic infection: the maximum daily dose is 1.5-2 g.
  • Balantidiasis: 750 mg 3 times a day for 5-6 days.
  • Pseudomembranous colitis: 500 mg 3-4 times a day.

Side effects

The drug is well tolerated by patients, but in some cases the following adverse reactions develop:

  • Discoloration of urine,
  • Strengthening vaginal discharge,
  • Changes in the clinical picture of blood,
  • On the part of the digestive tract - in rare cases, a violation of the chair, changes in taste, dry mouth, nausea, abdominal pain, increased gas generation,
  • Allergic reactions - a rash on the skin, urticaria, in rare cases, the development of angioedema,
  • From the side of the central nervous system - dizziness and headaches,
  • Local manifestations - discomfort, itching, burning, swelling, redness of the mucous membranes, foreign body sensation in the vagina.

Vacation conditions and price

The average cost of Klion D 100 (vaginal tablets No. 10) in Moscow is 425 rubles. Prescription.

Store in a dark place at a temperature of 15-30 ° C. Keep out of the reach of children. Shelf life:

  • pills - 5 years,
  • infusion solution - 3 years.

Features of the composition. Information about the form of release

Today, many patients are interested in information about the drug "Klion-D". Instructions for use, price, reviews - these are certainly important points. But before starting the therapy, it is necessary to understand the peculiarities of the composition.

The drug is available in the form of white biconvex almond-shaped tablets, which are intended for intravaginal administration. This is a combination medicine that contains two active substances at once, namely miconazole and metronidazole (100 mg of each substance in one tablet). Of course, there is a complex of auxiliary substances, including anhydrous colloidal silicon, povidone, sodium lauryl sulfate, magnesium stearate, crospovidone, sodium bicarbonate, lactose monohydrate, as well as tartaric acid, hydroxypropylmethylcellulose, and sodium carboxymethyl starch.

The tablets are packaged in convenient foil strips of 10 pieces each.

How does the medicine work? Properties

How does the drug Klion – D affect the body? Reviews of specialists suggest that the drug has pronounced antifungal, antibacterial and antiprotozoal properties.

Metronidazole is involved in the cycle of exchange and interacts with the DNA of bacterial cells and protozoa. This substance inhibits the synthesis of nucleic acids, which leads to the death of pathogenic microorganisms.

Miconazole, in turn, inhibits the production of ergosterol in the cells of disease-causing fungi. Thus, the composition of the lipid components in the membrane of the pathogenic cell is disturbed, leading to the death of the fungus.

With intravaginal administration, metronidazole penetrates the systemic circulation. Максимальная концентрация этого вещества в крови наблюдается спустя 6-12 часов после применения лекарства. Миконазол практически не проникает сквозь слизистые оболочки, не обнаруживается ни в плазме, ни в моче.

When do patients receive therapy?

In what cases is it advisable to use vaginal tablets "Klion-D"? Reviews of specialists and the results of scientific studies indicate that the drug can be used in the following cases:

  • vaginal candidiasis (thrush),
  • non-specific inflammation of the vaginal mucosa,
  • vaginitis caused by the activity of the yeast fungus of the genus Candida, as well as Trichomonas.

Drug "Klion-D": instructions for use

Reviews of doctors and patients indicate that the medicine really helps to cope with a lot of problems. Nevertheless, you should not use the drug without permission - only the doctor can make the right regimen.

How to use the medicine "Klion – D" (candles)? Reviews indicate that the instruction is quite simple. The tablet must be inserted deep into the vagina (it is desirable to carry out the procedure in the supine position). Pre-suppository is recommended to moisten in purified water. It is better to put the pill immediately before bedtime - so the drug will have time to completely dissolve and be adsorbed by the vaginal mucosa.

The course of therapy usually lasts 10 days. For maximum effect, vaginal tablets are combined with oral metronidazole. Such treatment is recommended not only for a sick woman, but also for her sexual partner - this is the only way to prevent the development of reinfection.

Contraindications

This drug is widely used in modern medicine, as it is considered effective and safe. Nevertheless, some contraindications exist, and their list should be reviewed even before the start of therapy.

  • The drug in any form is not prescribed to patients with allergies to any of the components. Also, do not use candles if women have a history of hypersensitivity to nitroimidazole derivatives.
  • Contraindications include leukopenia and other blood diseases.
  • The drug is not prescribed to patients with organic lesions of the central nervous system (epilepsy is also included in the list of contraindications).
  • The drug should not be taken in the presence of impaired coordination.
  • The list of contraindications include various forms of liver failure, especially when it comes to the use of large doses of medication.
  • Candles cannot be used by nursing mothers (active ingredients and their metabolites are excreted with breast milk) and women who are expecting a baby (especially during the first trimester).
  • The drug is used with caution in the treatment of patients with impaired blood microcirculation and diabetes.
  • It is worth noting that this medication causes intolerance to ethanol. That is why during therapy is contraindicated to drink alcohol.

Features of treatment: possible adverse reactions

Is it possible to develop any complications on the background of the use of vaginal tablets "Klion-D" (candles)? The instructions, reviews, and the results of clinical trials indicate that patients most often tolerate therapy well. However, the likelihood of adverse reactions should not be excluded.

  • Local reactions. Some patients complain of pain, irritation and a burning sensation in the vagina. The list of adverse reactions also include the appearance of mucous secretions with a faint odor. If during therapy a woman had sexual intercourse, then irritation of the penis is possible with the partner.
  • Allergies. There is a risk of allergic reactions, which are accompanied by the appearance of skin rash, redness, swelling and severe itching.
  • Digestive organs. Since metronidazole penetrates the systemic circulation, reactions from the digestive system are possible. Sometimes patients go to the doctor, complaining of nausea, cramps and abdominal pain, dry mouth, decreased appetite, as well as changes in taste. The list of possible complications include vomiting, abnormal stool, the appearance of an unpleasant metallic taste in the mouth.
  • Nervous system. The drug may affect the work of the nervous system. Some women complain of the appearance of weakness, dizziness, intermittent occurrence of severe headaches.
  • Other adverse reactions. Therapy may affect blood formation. During laboratory tests, leukocytosis and leukopenia are found in some patients.

It is also worth noting that in the process of metabolism of metronidazole, a water-soluble pigment may form in the body, which in some patients stains the urine in a red-brown color.

Medicine "Klion – D": price

Reviews, instructions, contraindications - this is important information. But it's no secret that many people are guided by the cost of a particular drug. Of course, the exact figure will depend on many factors, including the manufacturer and place of purchase.

The cost of packaging, consisting of 10 vaginal tablets, ranges from 500 to 700 rubles. It is worth noting that in most cases this amount is enough to complete the full course of treatment.

Description of effective analogues

Now you know how the drug Klion – D affects the body. Instructions, reviews, features of the composition - this information is definitely worth reading. But what should be done for patients who, for one reason or another, the above described medication does not suit?

Actually analogs exist. When vaginosis and candidiasis often used vaginal suppositories "Gaynomaks." Drugs such as Metromizol, Neo-Penotran, and Metromicon-Neo contain the same active ingredients (metronidazole and miconazole). Of course, it is better to entrust the choice of a substitute to the treating gynecologist. Self-medication is always risky.

What do the doctor's say? Patient Reviews

Before using a drug, it is always helpful to examine all the available information. Of course, it is worth getting acquainted with the opinion of experts. What do doctors say about Cleo-D? Reviews are positive. The drug allows you to quickly cope with the infection and to avoid the development of possible complications.

Patients also speak well of the remedy. Unpleasant itching, burning and other symptoms of infection of the vagina disappear after only a few days. Vaginal tablets are small, they can be easily administered intravaginally. Adverse reactions are recorded very rarely.

Convenient is the fact that the drug with the same composition is available in other forms, including tablets for oral administration and a solution for intravenous administration - with their help, therapy can be supplemented.

What is this medicine? general characteristics

The drug "Klion-D", whose price is about 400 rubles, is available in the form of suppositories. They are intended for vaginal administration. The main active ingredients are metronidazole and miconazole nitrate. One tablet contains 100 mg of each substance. Sold the drug in a carton. Each pack contains 10 suppositories in individual packaging. On one side of the tablet is the number "100". The manufacturer uses sodium lauryl sulfate, povidone, colloidal silicon dioxide, magnesium stearate, sodium bicarbonate, lactose monohydrate and some additional components as auxiliary substances.

Medication use: indications

In what situations is Klion-D prescribed? Instructions for use advises to use the drug for bacterial and fungal infections of the female genital tract. The annotation states that the drug is prescribed for the treatment of vaginitis. Doctors recommend medication when the patient discovered:

  • Trichomonas infections
  • vaginal candidiasis,
  • discharge with an admixture of pus, accompanied by an unpleasant odor.

In addition, candles are prescribed for the treatment of sexually acquired diseases (in combination). And also to prevent complications from surgical interventions and so on. Before using the medication, it is advisable to pass an analysis to determine the sensitivity of microorganisms to the active substance.

Limitations and side effects

Candles "Klion-D" should be used only on prescription. In this case, special attention should be paid to contraindications. They are always prescribed in the instructions for your reference. The abstract says that it is forbidden to carry out treatment in case of hypersensitivity to the main components and other azoles. Such therapy is contraindicated in case of leukopenia, liver failure, epilepsy, and some lesions of the central nervous system. Do not enter pills for girls under the age of 12 years and patients who are not sexually active. If necessary, such therapy is to choose analogues "Klion-D" in another form of release.

As side effects that have been officially registered, the following can be highlighted:

  1. Negative local reactions: discomfort, itching and burning.
  2. Effect on the digestive system. The patient may experience nausea and intestinal upset, changes in taste.
  3. Allergic reactions: itching, urticaria, swelling, redness of the genitals.
  4. Headache, exacerbation of existing pathologies.

Some patients suggest that the drug contributes to a change in urine color. This is the norm and passes on its own after completion of therapy

Method of use of the combined drug

You already know that the medicine is injected into the vagina. The dosage of the drug is determined by the doctor. Usually administered 1 tablet per day. The course of treatment must be at least 10 days. Wash your hands well before administering. Remove the pill from the commissure and hold it under running water for a few seconds. After that, take a comfortable position and enter the drug. The use of medication in pregnant women does not imply a reduction in dose or duration of therapy. The instruction does not recommend applying the medicine only in the first trimester. Doctors say that the drug does not have a teratogenic effect on the fetus, while respecting the doses in the second and third part of pregnancy.

Analogs "Klion-D"

The drug is replaced by other means in cases of need. An alternative medicine is always selected by the doctor. Remember that many products with the same composition have a different dosage. If you have an increased sensitivity to components, then you need to use candles based on other substances. For similar drugs containing metronidazole, include:

  • "Metromikon Neo".
  • "Neo-Penotran".
  • Metromizol.
  • "Ginalgin".
  • "Klevazol".
  • "Pulsiteks" and others.

Manufacturers also produce analogues of Klion-D based on other components. In this case, drugs have a similar effect on the sexual sphere of women. These include:

  • "Ginesol".
  • Santequin.
  • "Gyno-Travogen".
  • "Zalain."
  • "Candibene".
  • "Pimafutsin".
  • "Diflazon".
  • "Difluzol".
  • Livarol.
  • "McMirior".
  • "Clotrimazole" and so on.

Consider some drugs in more detail.

"Difluzol" and "Diflazon": instructions for use

The active ingredient of these drugs is fluconazole. This is an antifungal component. Medication "Difluzole" from thrush and other fungal diseases of the vagina and mucous membranes is prescribed. The drug "Diflazon" instructions for use can be used for prevention. Doctors recommend conducting a similar therapy for recurrences of thrush more than three times a year.

The dosage of drugs is chosen individually. The instructions indicate that fluconazole is taken in a volume of from 0.05 to 0.1 g per day for 2-4 weeks. Both drugs are not prescribed during lactation, but are used during pregnancy. These drugs are different from the drug "Klion-D" in that they do not contain an antibiotic.

Use of the drug "McMiror"

This drug contains in its composition two main components: nifuratel and nystatin. The drug has antifungal, antibacterial and antiprotozoal effects. In this characteristic, it completely coincides with the drug "Klion-D". Vaginal suppositories "McMiror" are prescribed for vulvovaginal infections, which were caused by Trichomonas and Candida mushrooms. The drug is contraindicated in case of hypersensitivity. In other cases, its use is not limited.

Dosage means prescribed by a specialist. The daily dose is 1 suppository. The duration of therapy usually does not exceed 8 days. If necessary, candles can be replaced with a vaginal cream, which is sold complete with a convenient applicator.

Suppositories "Ginesol 7"

The composition of this drug is miconazole nitrate. One suppository contains 100 mg of this component. Prescribed medication for the treatment of fungal lesions of the vagina: candidiasis, balanitis, infections caused by gram-positive microorganisms. Contraindications to the use of the drug "Ginesol 7" (candles) instructions for use calls late pregnancy, hypersensitivity and renal failure. The drug is inserted into the vagina before bedtime, one suppository each. At the same time it is necessary to follow all the rules of asepsis. The duration of treatment does not exceed one week.

The drug "Vokadin" and "Betadine": features

These two drugs contain in their composition povidone-iodine in the amount of 200 milligrams. "Betadine" and "Vokadin" - candles, which are antiseptics. They are assigned to the treatment of the vagina after various gynecological procedures (biopsy, puncture, curettage, abortion, and so on). Contraindications to their use are diseases of the thyroid gland and kidney, breastfeeding, child age and pregnancy. These analogues do not treat bacterial and fungal infections of the vagina. Drugs are prescribed in a dose of 1 suppository twice a day. The duration of therapy depends on the condition of the patient.

Oronazole tablets

The active ingredient of these pills is ketoconazole. The drug belongs to antifungal agents. But he cannot cope with a bacterial infection. This is what distinguishes it from the Klion-D product, the price of which was stated in the article.

The indication for the use of the drug is thrush and other fungal pathologies of the female genital tract. The medicine is not used for liver and kidney diseases, during pregnancy and lactation, as well as in young children. Note, only in the form of tablets for oral administration is issued "Oronazol". Candles you can not buy. Prescription medication and dose selection is made by a doctor in accordance with the instructions.

Choice of medicine: reviews

To choose the right drug for treatment, you need to contact a specialist. Doctors say that when prescribing antibiotics, it is necessary to pass an analysis to determine the sensitivity of microorganisms. This will allow for effective treatment. If a bacterial infection is not found in a woman's smear, and only colonies of fungi are present, then she needs appropriate therapy. Independently find the right medicine is almost impossible. Experts remind that you do not need to chase the cost of drugs. If the medicine is expensive, it does not guarantee that it will help.

Patients say that often after various manipulations they were prescribed the drug "Betadine". The drug helped to conduct antiseptic measures and prevent the development of infection. The drugs "Difluzol" and "Diflazon" get positive feedback due to its effectiveness and safety. These funds can be used without fear during pregnancy. It is worth noting that it was during the childbearing that many women first encountered thrush.

The drug "McMiror" has good reviews because of its action. The drug is not absorbed into the systemic circulation. It acts exclusively in the vagina. In this case, the drug has a bactericidal and antifungal effect. Tablets of this trade name are often used to treat intestinal infections.

What do consumers say about the drug "Klion-D"? Women who have used this medication report that it was given to them in conjunction with oral metronidazole-based antibiotic. This combination is chosen to enhance the effect. It must be remembered that any antibacterial agents are prohibited for use in the first trimester of pregnancy. Therefore, the drug "Klion-D", as well as other drugs with metronidazole, are prescribed only after 16-18 weeks. After completing the treatment, be sure to pass a re-analysis. Women say that the advantage of the drug "Klion-D" is its form of release. Unlike other fat-based candles and vaginal creams, the drug does not flow and does not stain the linen. The medicine is completely distributed in the vagina.

Small conclusion

The drug "Klion-D" is a popular and effective tool used in various gynecological infectious diseases. One of its analogues is considered the drug "Betadine" (candles). Цена, отзывы и способ использования препарата «Клион-Д» представлены вашему обзору. Обратите внимание, что не все аналоги имеют такой же состав. Оригинальный препарат оказывает противомикробное, антибактериальное и противогрибковое действие.Others are fighting directly with thrush or are antiseptics. And in order to get the correct and qualified appointment, you need to consult a doctor. Be healthy!

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