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Reviews Bromocriptine

Bromocriptine is a derivative of ergot, a stimulator of peripheral and central dopamine D2 receptors. Inhibiting the secretion of prolactin, helps to normalize the monthly cycle, suppresses physiological lactation, reduces the number and size of cysts in the mammary gland due to restoring the balance of estrogen and progesterone levels.

Bromocriptine: drug dosage and instructions


This tool must be taken inside while eating.

  • In the process of treatment of premenstrual syndrome, the use of the drug according to the instructions recommended for the 2nd week of the cycle. The initial dosage is 1.25 mg daily, while it can be increased to 5 mg. The therapeutic course lasts until the onset of menstruation.
  • In the process of treating infertility in a woman and during violations of the monthly cycle, the agent is used at a dosage of 1.25 mg up to three times daily. Given the need, the dosage of the drug can be increased to 7.5 mg daily. Use of medication should be made before normalization of menstruation. In order to prevent the occurrence of violations, bromocriptine can be used for prophylaxis for several monthly cycles.
  • In the process of treating hyperpolactinemia in men, the drug is used on 1.25-10 mg three times daily.
  • During treatment with acromegaly, an initial dosage of 1.25 mg is recommended 3 times a day. In the absence of undesirable side effects and with normal tolerance of the drug, the dosage is increased to 20 mg per day.
  • During the detection of benign tumors in the area of ​​the mammary glands, the drug is used in a dosage of 1.25-7.5 mg daily. In this case, the dose should be gradually increased, under the supervision of a physician.
  • For treatment with prolactin, the dosage of the drug may be 1.25-5 mg 3 times a day. Therapy is carried out to restore the amount of prolactin.

The exact duration of treatment and the dose of the drug must be chosen only by the doctor, taking into account the individual characteristics of the patient and the clinical manifestations of the disease.

Postpartum states and cessation of lactation

To complete lactation Bromocriptine is used according to the following scheme:

  • One day of taking the medicine - the dosage of the drug is 1.25 mg 2 times a day.
  • The next 14 days of treatment - 2.5 mg 2 times daily.

Drug use need to start producing no earlier than four hours after an abortion or childbirth. 2-3 days after discontinuation of the drug, small amounts of milk from the breast are likely. In this case, the resumption of the use of the drug during the week at a dosage of 2.5 mg 2 times a day will contribute to the absolute cessation of secretions.

  • When mastitis develops, the use of the medication is carried out according to the same scheme as described for the completion of lactation. Given the need for a course of treatment supplemented with antibacterial agents.
  • During the postpartum engorgement of the breast, the medicine is used once a day at a dosage of 2.5 mg. You can repeat the reception of funds in 10-12 hours. This does not lead to the completion of the formation of breast milk.

Bromocriptine: indications for use


Can be used during the treatment of such diseases:

  • Prolactin-dependent diseases that are not accompanied or are accompanied by an increase in the amount of prolactin.
  • Violations of premenstrual syndrome, menstrual cycle, polycystic ovary, infertility (including prolactin-independent), insufficiency of the luteal phase.
  • Hyperprolactinemia provoked by the use of certain groups of drugs: drugs for high blood pressure, psychostimulants.
  • Oligomenorrhea.
  • Conservative treatment of pituitary micro- and macroadenomas.
  • Hyperprolactinemia in men, disorders of libido, impotence, oligospermia.
  • Comprehensive treatment of acromegaly with surgery and radiation therapy. Sometimes bromocriptine is used as an alternative to radiation treatment or surgery.
  • Preoperative conditions to reduce the size of the tumor.
  • Mastitis, postpartum breast engorgement.
  • Prevention of lactation after abortion, suppression of physiological lactation.
  • All stages of Parkinson's disease.
  • Mastalgia accompanied by fibrocystic mastopathy or premenstrual syndrome.

Bromocriptine: contraindications

Contraindications to the use of this drug are: the development of psychosis, an increase in blood pressure in the postpartum period, the presence of cardiovascular diseases, tremor (familial and essential), liver failure, stomach ulcers.

Bromocriptine is also prohibited for use during toxicosis in pregnant women, children under 15 years old and in the case of personal intolerance to the active or additional component of the drug, as well as ergot derivatives.

Bromocriptine during pregnancy and lactation

Women of childbearing age must not forget about the careful attitude to the choice of reliable drugs for contraception when taking Bromocriptine. It is best to give preference to non-hormonal birth control drugs.

In the case when pregnancy occurs on the background of the use of the remedy, and the woman wants to save the baby, then the use of bromocriptine must be completed immediately. This recommendation does not apply to cases where the potential benefits of using the medication are greater than the likely harm to the fetus.

  • The use of bromocriptine during the first trimester of gestation does not contribute to the negative effects of pregnancy and further outcome.
  • During lactation, this tool can only be used in the case of objective indications for use, under the supervision and as directed by a physician.

Bromocriptine: Side Effects

The use of the drug may provoke the occurrence of such undesirable side effects: vomiting, dizziness, high fatigue, nausea. These side effects Do not need to abolish the use of pills. Also, the development of heart attack, stroke, sudden sleep, constipation, hallucinations, drowsiness, psychosis, psychomotor agitation, caries, visual disturbances, nasal congestion, dry mouth, seizures in the region of the calf, allergic reactions.

With prolonged use of tablets increases the likelihood of Raynaud's syndrome. In the process of treatment of Parkinson's disease - nasal discharge, confusion, stomach ulcers, fainting, appetite disturbances, stomach bleeding, increased urination, pain in the back and abdomen, nausea.

Interaction with other drugs

Simultaneous use with drugs such as Josamycin, Erythromycin, as well as other drugs from the group of macrolide antibiotics provokes increase in the amount of bromocriptine in the blood plasma.

During simultaneous use with ethanol, the negative side effects of Bromocriptine tablets are likely to increase.

In the process of treating an increased amount of prolactin, it is not necessary to take funds at the same time, where domperidone is in the composition because of the risk of lowering the effectiveness of the drug.

Bromocriptine is not recommended simultaneously with ergot alkaloids, furazolidone, MAO inhibitors.

When taken simultaneously with reserpine, methyldopa, molindone, metoclopramide increases the risk of undesirable side effects.

special instructions

To reduce the risk of nausea, it is advisable to use antiemetic drugs for 45-50 minutes before using bromocriptine.

Women must not forget that with the use of medication increases the chance early postpartum conception. The drug contributes to the rapid normalization of the ovaries.

When pregnancy occurs during the treatment of pituitary adenoma, then after completing the use of bromocriptine, it is necessary to monitor the condition of the adenoma all the time.

When this remedy is used to suppress postpartum lactation, it is necessary to constantly monitor the level of blood pressure during the first week.

When the patient's history mental disorders are presentthen a significant dose of medication is prescribed with great care and under the supervision of a physician.

In the process of treating diseases that are not accompanied by an increase in the amount of prolactin, Bromocriptine is used in the minimum effective dosage.

In the case when Bromocriptine has a negative effect on the lungs (the presence of infiltrate in the lungs, pleural effusion), the use of the drug is immediately stopped.

Before starting to use the drug to treat benign tumors, it is necessary rule out possible malignant tumors.

The patient is obliged to carefully observe the hygiene of the oral cavity. When a dry mouth worries a person for more than 2 weeks, it is recommended to consult a doctor.

Against the background of Bromocriptine use, the patient is obliged to systematically monitor the functioning and condition of the cardiovascular system, liver, kidneys, and take a blood test.

In the case when, against the background of the use of the medicine, a person has a visual impairment, a headache and an increase in blood pressure, then immediately complete the reception bromocriptine and consult a doctor.

Bromocriptine may contribute to the emergence of side effects such as drowsiness, dizziness, impaired vision, because with the use of tablets, it is necessary to refrain from driving and performing work that require high concentration.

Bromocriptine: the price of the drug

The price of this medicine is formed taking into account the manufacturer of the drug:

  • Poly bromocriptine (Production Italy) - 370-420 rubles,
  • Bromocriptine Ozone (Production Russia) - 310-330 rubles,
  • Bromocriptine-Richter (Production Hungary) - 340-370 rubles.

Bromocriptine: drug reviews

Mostly Bromocriptine reviews refer to its side effects. By and large, many women who use the drug to treat infertility, to stop lactation, and also for other purposes, while taking the medication, have persistent dizziness and nausea.

Some people celebrate constant fatigue, weakness, unstable emotional state, low pressure, nasal congestion, vomiting, faintness, constipation. In certain reviews, there is a connection between the use of the drug and the depression that has emerged against this background.

If you exceed the dosage, there is a strong psychomotor overexcitement, psychosis, sometimes reaching hallucinations.

In order to reduce side effects in a certain way, it is advised to use the medicine for the night, and to reduce nausea, take an antiemetic drug one hour before using bromocriptine.

Pronounced side effects are most often noted only in the first week of taking bromocriptine. When the side effect of the drug is retained, it can be replaced with another similar drug. But only a doctor can make a replacement or determine the appropriateness.

In general, data on the therapeutic effects of this tool are good. According to certain surveys, approximately 65-75% of women successfully became pregnant due to the use of bromocriptine for the treatment of infertility. Whether it is necessary to use bromocriptine to stop lactation or treat other diseases is up to you.

Bromocriptine was prescribed at elevated levels of prolactin. She took him a month, the first days were very sick. The doctor recommended taking bromocriptine with Cerucul. After treatment, she passed the tests - everything is fine. If you do not take into account light dizziness and constant nausea, then Bromocriptine does not give any side effects.

It was necessary to urgently stop breastfeeding. Folk recipes did not help me - all the time the milk arrived. The doctor prescribed bromocriptine. She took the drug daily in the morning and in the evening a month. Milk over time began to disappear, and by the end of the course of treatment was completely gone. But I had to suffer a lot from the side effects: I often ran to the toilet at night, stuffed my nose, constantly nauseated. But the mood was excellent, and no irritability!

I take this drug to suppress lactation, a little nausea, but without vomiting, I really want to sleep. On the first evening, my head ached a lot, the following days it was easier to bear the next days. Milk stays less and less, daily I decant and stretch my chest. I recommend to take half a pill first in the morning and before bedtime, then you will feel how the body takes the medicine and whether you need to take it further, because then you have to take it all over the whole tablet.

Analogs Bromocriptine

Coincides according to indications

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Coincides according to indications

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Coincides according to indications

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pharmachologic effect

Stimulator of central and peripheral dopamine D2-receptors, ergot alkaloid derivative. Reduces the secretion of prolactin, as well as increased secretion of growth hormone, without affecting the normal levels of other pituitary hormones. Suppresses physiological lactation, helps to normalize menstrual function, reduces the size and number of cysts in the mammary gland (by eliminating the imbalance between progesterone and estrogen). At doses higher than those required to suppress the secretion of prolactin, bromocriptine causes a pronounced stimulation of the dopamine receptors, in particular in the areas of the striatum, the black core of the brain, the hypothalamus and the mesolimbic system. It has anti-Parkinsonian effect, inhibits the secretion of growth hormone and ACTH.

After taking a single dose, the level of prolactin in the blood comes after 2 hours, the maximum effect after 8 hours, the anti-Parkinsonian effect develops in 30-90 minutes, the maximum effect after 2 hours, the decrease in the level of STH occurs after 1-2 hours, the maximum effect after 4-8 weeks of therapy.

Pharmacokinetics

After oral administration, the absorption of bromocriptine from the gastrointestinal tract is 28%. Exposed to the effect of "first pass" through the liver. Bioavailability - 6%. The time to reach the maximum concentration in the blood plasma is 1-3 hours. T1/2 biphasic: 4-4.5 h in the α phase, 1 h in the terminal phase.

Plasma albumin binding is 90-96%.

Excreted mainly with feces - 85.6% and to a small extent with urine - 2.5-5.5%.

Menstrual disorders, female infertility: prolaktinzavisimye diseases and conditions, accompanied or not accompanied by hyperprolactinemia (amenorrhoea accompanied and not accompanied by galactorrhea, oligomenorrhea, insufficiency of the luteal phase, secondary hyperprolactinemia induced by drugs) prolaktinnezavisimoe female infertility (polycystic ovarian syndrome, anovulatory cycles - as an additional therapy for anti-estrogens).

Premenstrual syndrome: breast tenderness, edema associated with the phase of the cycle, flatulence, mood disorders.

Male hyperprolactinemia: prolactin-dependent hypogonadism (oligospermia, loss of libido, impotence).

Prolactinomas: conservative treatment of prolactin-secreting pituitary micro- and macroadenomas, in the preoperative period to reduce the size of the tumor and facilitate its removal, postoperative treatment if the level of prolactin remains elevated.

Suppression of lactation: prevention or termination of postpartum lactation for medical reasons - prevention of lactation after an abortion, postpartum engorgement of the mammary glands, starting postpartum mastitis.

Benign breast diseases: mastalgia in isolation or in combination with premenstrual syndrome or benign nodular or cystic changes), benign nodular and / or cystic changes, especially fibrocystic mastopathy.

Parkinson's disease and parkinsonism syndrome, incl. after encephalitis (as monotherapy or in combination with other anti-Parkinsonian drugs).

Side effect

From the digestive system: nausea, vomiting, dry mouth, constipation, diarrhea, abnormal liver function.

From the side of the central nervous system: dizziness (usually occur in the first week of treatment), headache, drowsiness, psychomotor agitation, dyskinesia, decreased visual acuity, hallucinations.

Since the cardiovascular system: orthostatic hypotension, arrhythmia, in some cases, with prolonged use - Raynaud's syndrome (especially in predisposed patients).

Allergic reactions: skin rash.

Other: nasal congestion, cramps in the calf muscles.

Use during pregnancy and lactation

When pregnancy occurs, bromocriptine is recommended to cancel as soon as possible after conception, except in cases where there are medical indications for continued therapy.

Application during the lactation period according to indications is possible. It should be borne in mind that bromocriptine is excreted in breast milk.

Drug interaction

При одновременном применении с бромокриптином уменьшается эффективность антипсихотических средств антагонистов допаминовых рецепторов.

With simultaneous use with derivatives of butyrophenone, phenothiazine, it is possible to reduce the effects of bromocriptine.

In patients receiving bromocriptine and sympathomimetics at the same time, there were cases of severe headache, hypertension, convulsions, impaired heart function, and psychosis.

With simultaneous use with domperidone, it is possible to reduce the effect of bromocriptine when it is administered in order to reduce the level of prolactin.

With simultaneous use with levodopa, antiparkinsonian effect is enhanced, with antihypertensive drugs - hypotensive effect is enhanced.

With simultaneous use with erythromycin, josamycin, other macrolide antibiotics, octreotide may increase the concentration of bromocriptine in the blood plasma, with ethanol - possibly increased side effects of bromocriptine.

Bromocriptine reduces the effectiveness of oral contraceptives.

Reviewer: Vita Kotlyarova (positive review)

Composition and release form

"Bromocriptine" is considered a semi-synthetic drug. The main active ingredient in it is bromocriptine. This chemical compound is derived from ergot, a fairly strong alkaloid, which in high doses has toxic properties.

On the modern pharmaceutical market, Bromocriptine is presented in pill form. Each of them contains 2.5 milligrams of active ingredient. In medicine packs, there are usually 30 tablets.

Therapeutic effect

The drug "Bromocriptine" has the ability to inhibit the production of prolactin. Under the influence of this medication, dopamine receptors are activated, which suppress the production of all the hormones of a separate part of the pituitary gland, but most of all this effect affects the synthesis of prolactin. Also, the drug "Bromocriptine", which will be reviewed below, inhibits the production of growth hormone when it is increased. In addition, this drug has a positive effect on the glands of the reproductive system.

Indications for use

Bromocriptine tablets can help people suffering from infertility. Patient reviews indicate that in the case when this pathology is caused by changes in the sexual cycle, this medicine is very effective. Also, the drug "Bromocriptine" is prescribed for insufficiency of the luteal phase, amenorrhea and for infertility associated with polycystic ovaries. Among other things, this medicine is used if an increase in blood prolactin is caused by the intake of certain medications. If patients have a very pronounced premenstrual syndrome, then the drug "Bromocriptine" is simply irreplaceable. It helps to normalize the condition and significantly improve the well-being of women during this period.

It should be remembered that not only women are prescribed the drug Bromocriptine. Reviews of experts say that men suffering from excessive content of prolactin in the body and developed on this background, a violation of sexual desire or sexual impotence, also need this drug. The fact is that there is a special kind of neoplasm of the pituitary gland, known as "prolactinoma". It can appear in both men and women, so Bromocriptine tablets are prescribed to patients of both sexes.

Instructions, reviews healed indicate that this drug is effectively used for the relief of milk production, as well as for the treatment of acromegaly, Parkinson's disease and certain tumors in the mammary glands.

To stop lactation, it is necessary to take 1.25 milligrams of the medicine “Bromocriptine” twice in the first day. In the future, this dosage should be doubled and absorb the drug by 2.5 milligrams in the morning and evening. The duration of such therapy is usually two weeks. If, after 2-3 days after its termination, the patient has milk again, the medicine must be taken for another seven days.

To alleviate the symptoms of Parkinson's disease, it is also necessary to start with a minimum dose of the drug, which is 1.25 milligrams per day. This amount of medicine must be taken within a week, after which it should be gradually increased, bringing to 10-40 milligrams per day. However, only a doctor can determine the intensity of increasing the dose of the drug "Bromocriptine". Patient reviews indicate that when you feel unwell and other side effects, it should be immediately reduced, then the condition quickly normalizes.

For healing from other diseases, a suitable dosage is selected individually, based on the symptoms of the pathology and the severity of the patient's condition.

Contraindications

People suffering from sudden drops in blood pressure, eclampsia or preeclampsia, as well as complex vascular or heart diseases, are not recommended to use the drug "bromocriptine". It is not advisable to take it in patients with an ulcer of the intestine or stomach and patients suffering from mental illnesses and disorders. This medicine is also contraindicated for children. It is not used to treat patients younger than fifteen years and those who have an individual intolerance to the individual components of the drug.

Side effects

There are a number of side effects that may occur in patients taking the drug "bromocriptine". Some patients experience nausea in the first days of treatment, but after several days of treatment, it passes. In addition, at the very beginning, some lethargy and lack of coordination may appear, and in some patients migraine-like pains, allergic manifestations, and tremor of the extremities are noted. If the appearance of side effects reduces the amount of the drug being taken, then all unpleasant symptoms will gradually disappear. You should also remember that while taking the drug "Bromocriptine" you can not drink alcohol and get behind the wheel of a car.

Interaction with other drugs

The drug "Bromocriptine" interacts with many drugs. Reviews about him suggest that it can be safely taken along with herbal dietary supplements and other means of natural origin. However, any experiments with medications are fraught with unpredictable consequences. Therefore, all changes to the prescribed course of treatment must be coordinated with a specialist.

"Bromocriptine" and pregnancy

Reviews of numerous women indicate that carrying a child is not an obstacle to the use of the drug "Bromocriptine". This medicine is absolutely safe for the growth and development of the baby, as well as for the dynamics of pregnancy in general. However, doctors try to be careful and not to prescribe the drug “Bromocriptine” during this period. The exception is when the expectant mother suffers from serious illnesses. During pregnancy, she is usually recommended to stop taking this drug, but when anxious symptoms appear, it is resumed again.

However, the reception of proven "Bromocriptine" in the period of bearing a child has a serious minus. The fact is that it suppresses lactation, which means that after delivery the patient will not be able to feed her baby on her own. But if we are talking about preserving the life and health of the mother, then it is necessary to make a choice in favor of treatment with this drug.

Cessation of lactation

Sometimes it may be necessary, and after childbirth, the drug "Bromocriptine". The feedback for stopping lactation is positive for this remedy. Often during breastfeeding, young mothers face unpleasant diseases, such as mastitis. In this case, it takes some time to take the medicine "Bromocriptine", and in combination with antibiotics.

Also, some women after childbirth observed breast engorgement. With this annoying phenomenon you can cope with the help of the medicine described by us. A single use of the drug "bromocriptine" in the amount of 2.5 milligrams can significantly improve the patient's condition. If this does not happen, then after 6 or 12 hours, taking the drug in the same dose must be repeated.

Such therapy will not prevent breastfeeding, if it lasts no more than three days. If you want to completely give up breastfeeding, the patient must take Bromocriptine tablets for eleven days. Testimonials for stopping lactation confirm that such therapy quickly leads to the desired result.

Infertility Treatment

Conception and childbearing are impossible if a woman suffers from hyperlactinemia, that is, an excess of prolactin in the body. Such a condition can trigger the taking of certain medications, a tumor in the pituitary gland, or a lack of thyroid hormones. Men can also suffer from this disease. Regarding healing from this pathology, the preparation described by us has earned the highest accolades from specialists.

"Bromocriptine" reduces the amount of prolactin in the blood in the first days of therapy, and the full course of treatment causes it to fall by half compared with the initial level. True, in some patients in the first days of using the medication, there is a desire for vomiting. Over time, they disappear, but badly spoil the impression of taking this drug.

Thus, you can use tablets "Bromocriptine" for infertility. Reviews of experts state the effectiveness of the use of this drug as a remedy for pathologies of the reproductive system caused by disorders in the human endocrine system, in particular the malfunction of the pituitary gland. This fact is the cause of hyperlactinemia and, as a result, infertility.

Patient Reviews

Doctors often prescribe medication Bromocriptine-KV to their patients. Feedback on the use of this drug is mixed. Some patients immediately feel the positive impact of this drug and remain of good opinion about it. Others experience the full power of the side effects that this drug can cause, and treat it negatively.

Positive reviews of the drug "Bromocriptine", as a rule, prevail. Especially it helps women who for one reason or another need to immediately abandon breastfeeding. In addition, many felt its effectiveness in reducing prolactin in the blood. Patients who manage to become pregnant during the course of treatment speak of this drug with particular gratitude.

Many are satisfied with the price - it is low and varies between 293-350 rubles. However, there is another, sharply negative opinion. Some patients tolerate therapy with Bromocriptine very difficult. They argue that during treatment with this remedy, they manifested a variety of side effects: nausea, vomiting, drowsiness, impaired coordination, even the appearance of hallucinations.

It is hard to say how objective such reviews are. But each person is individual, therefore, impressions about the use of the same medicines, people have different. The main thing is to remember that it is impossible to treat yourself with “Bromocriptine”. It is much safer to do this under the supervision of a competent specialist.

Now you know what constitutes Bromocriptine. Instructions, reviews about this drug were discussed in this article. This tool has long and effectively used in medicine and is indispensable in the treatment of a number of serious diseases. Remember this and be healthy!

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Bromocriptine instructions

Bromocriptine is a derivative of ergot, which has a wide range of indications, including failures of the menstrual cycle and female infertility. The drug is indicated in the absence of menstruation, with an increase in the interval between them, luteal insufficiency, increased levels of prolactin caused by medications, Stein-Leventhal syndrome, premenstrual syndrome, testicular insufficiency caused by elevated levels of prolactin (in men). Bromocriptine is also used to suppress lactation, for the treatment of mastodynia (including in combination with PMS), fibrocystic disease, Parkinson's disease, acromegaly (as part of complex therapy, including surgical treatment and radiotherapy). Bromocriptine inhibits the release of lactogenic hormone prolactin, inhibiting the process of production of breast milk. Restores normal menstrual function. Reduces the volume and number of cystic formations in the breast due to the alignment of the imbalance between progesterone and female sex hormones. But bromocriptine does not affect the speed and nature of the recovery of the uterus after birth. In submaximal dosages, it activates dopamine receptors located in the striatum and the substantia nigra, hypothalamus and mesolimbic tract and normalizes the balance of neurotransmitters in these cerebral structures. Reduces signs of Parkinson's disease: involuntary movements of the limbs and torso, lack of response to stimuli or resistance, slow movements. A single dose of bromocriptine clinically significantly reduces the concentration of prolactin after two hours. The peak of the effect of the drug is noted after eight hours. Antiparkinsonic action develops in 0.5-1.5 hours and reaches its peak after two hours.

A decrease in the secretion of growth homon under the action of bromocriptine is noted after 1-2 hours, the peak of the antisomatotropic action - after 1-2 months. Bromocriptine has a low bioavailability: about 30% of the active component is absorbed from the digestive tract, and a significant part of it is absorbed in the liver (more than 90% undergo metabolic transformations with the formation of inactive metabolites). Excreted mainly with feces. Bromocriptine is contraindicated in patients with individual intolerance to the active substance, diseases of the heart valves, late toxicosis of pregnant women, hypertension after childbirth, Huntington syndrome, psychosis, cardiovascular pathology, insufficient liver function, ulcerative-erosive lesions of the gastrointestinal tract. In pediatric practice, the use of bromocriptine is very limited and is allowed only after patients have reached the age of fifteen. Women who are at reproductive age should be guaranteed reliable contraception (preferably, without the use of hormonal contraceptives) while taking bromocriptine. If the patient wants to save the child, the course of medication should be interrupted. Pharmacotherapy using bromocriptine is permissible only during the first two months of pregnancy. The optimal time of taking the drug - with meals. To prevent vertigo, nausea and vomiting at the beginning of the medication course, it is recommended to resort to antiemetics for 60 minutes before taking bromocriptine. During treatment, blood pressure, liver and kidney function should be monitored.

Pharmacodynamics and pharmacokinetics

The active ingredient is derived from the ergot alkaloid and stimulates peripheral and central D2-dopamine receptors.

The main principle of influence is to suppress physiological lactation, inhibition of the secretion of the hormone prolactin, normalization menstrual cycle, reducing the number and size of cysts in the mammary glands (achieved by eliminating the imbalance between the level of estrogen and progesterone), inhibition of increased secretion of growth hormone.

Bromocriptine in large doses can stimulate the dopamine receptors of the black core of the brain, the striatum, the mesolimbic system, and the hypothalamus. The drug inhibits the secretion of the hormones ACTH and growth hormone, has anti-Parkinsonian effect.

Taking a single dose causes a decrease in prolactin after 2 hours, antiparkinsonian effect recorded after 30-90 minutes, a decrease in the rate of GH - after 2 hours.

Side effects

Constipation, nausea, orthostatic hypotension, dizziness, vomiting, increased drowsiness, headaches, allergic reactions, dry mouth, dyskinesia, hallucinations, psychomotor agitation, impaired visual perception, convulsions in the calf muscles, skin rash, orociasis, periodontal disease, allergic reactions.

Prolonged therapy can provoke fainting, confusion, gastrointestinal bleeding (presence of blood in the vomit, black stools), peptic ulcer, retroperitoneal fibrosis (слабость, снижение аппетита, эпигастральные боли, тошнота, рвота, учащенное мочеиспускание).

Инструкция по применению Бромокриптина (Способ и дозировка)

Tablets administered orally, during the meal, per day no more than 100 mg.

With female infertility, menstrual disorders - 2-3 times a day at 1.25 mg, with the ineffectiveness of the amount of the drug is increased to 5-7.5 mg per day (multiplicity - 2-3 times). Therapy is carried out until full recovery of ovulation, or until normalization of the menstrual cycle. For the prevention of relapse, treatment may include several successive cycles.

With premenstrual syndrome the medicine is prescribed on the 14th day of the menstrual cycle at a dose of 1.25 mg. Before the onset of menstruation, the amount of the drug is gradually increased to 5 mg per day.

With hyperprolactinemia in males the drug is prescribed 2-3 times a day for 1.25 mg, with a gradual increase to 5-10mg per day. With prolactinomas: 2-3 times a day, 1.25 mg to achieve an adequate reduction in the level of prolactin in the blood.

With acromegaly The initial treatment regimen includes a threefold administration of the drug at a dose of 1.25 mg, in the future it is possible to increase to 20 mg

To suppress lactation On the first day, Bromocriptine is prescribed twice at 1.25 mg, then at 2.5 mg twice a day for two weeks. To stop the process of lactation, the drug is prescribed a few hours before an abortion or childbirth. There may be a slight secretion of milk in 2-3 days after discontinuation of the medication.

Bromocriptine take a dose of 2.5 mg with postpartum breast engorgement, the procedure can be repeated after 6-12 hours if necessary.

With the onset of postpartum mastitis The treatment regimen is identical to that for suppressing lactation. An antibiotic is also prescribed.

With benign breast diseases Bromocriptine is taken three times a day at 1.25 mg, with a gradual increase in the daily dose to 5-7.5 mg.

In Parkinson's Disease ensuring optimal tolerability of the drug is achieved by prescribing the minimum dosage on the first day - 1.25 mg. Gradually increase the amount of the drug, an adequate therapeutic effect is achieved in 6-8 weeks. In the absence of the desired effect, an increase in the daily amount of the drug to 2.5 mg per day is possible. When registering severe side effects, the daily amount of the drug is reduced. After stabilization, it is possible to return to the initial dosages.

Patients with motor disorders characteristic of levodopa, it is recommended to reduce the dose of levodopa in the treatment of bromocriptine. In this way, complete elimination of levodopa can be achieved.

The instructions for Bromocriptine Richter and Bromocriptine KV are similar.

Bromocriptine and pregnancy

When pregnancy occurs, drug therapy is stopped, unless the need for treatment outweighs the possible risk to the fetus. During treatment with bromocriptine, it is recommended non-hormonal contraception.

When diagnosing pregnancy in the background pituitary adenoma, after the cessation of treatment requires regular monitoring of the condition of the adenoma, including the necessary study of the visual fields. Before therapy for benign breast tumors, it is necessary to exclude the malignant nature of the tumor and any cancerous processes in the body.

Bromocriptine, doctors reviews

Indicate the effectiveness of the drug. Breast compaction disappears, lactation ends, prolactin levels decrease.

Positive feedback about Bromocriptine-Richter to stop lactation is very frequent, although there are also patients who are not helped by the medicine.

Negative reviews of bromocriptine indicate frequent and severe side effects.

Pharmacological effects

The drug is a semi-synthetic ergot derivative that stimulates the central dopamine receptors, reduces the formation of prolactin and contributes to the inhibition of excessive secretion of growth hormone. All this allows the drug to acquire the status of a productive dopamine receptor agonist in the treatment of endocrine effects and Parkinson's disease.

In gynecology and endocrinology, the use of the drug is due to the effect of the drug on the pituitary and hypothalamus for:

  • reduce prolactin secretion
  • reduce the secretion of growth hormone or somatotropin,
  • oppression of physiological lactation and normalization of menstrual function,
  • reduce the growth rate of prolactinomas and reduce the number of cysts and their size in the area of ​​the mammary glands.

In neurology, the use of the drug "Bromocriptine" is based on such qualities as:

  • the possibility of increasing motor activity, eliminating stiffness, some slowness of gait and movements, reducing tremor, improving the overall quality of life of patients and ensuring positive changes in the prognosis of Parkinson's disease,
  • A combination of the drug can be used along with other types of anti-Parkinsonian drugs. If the disease has a pronounced stage, then it is advisable to connect it with the "Levodopa". The price of "Bromocriptine" will be presented below.

If you take the drug in the dosage prescribed by the doctor, the level of prolactin decreases after two hours. The therapeutic effect reaches its maximum level eight hours after the patient takes the pill. In the period from thirty to ninety minutes, the anti-Parkinsonian effect develops. Its maximum effect is observed in two hours. A decrease in somatropic hormone is observed an hour or two after the use of the drug. In general, the highest therapeutic effect occurs about a month or two after treatment.

Tablets are intended for oral administration, not more than 100 mg per day.

If there is female infertility, menstrual disorders - twice a day, 1.25 mg. If the treatment is ineffective, the amount of the drug is increased to 5-7.5 mg per day (multiplicity - two or three times). Therapy is carried out until ovulation is fully restored or until the menstrual cycle is normalized. For the prevention of recurrence, treatment may include several consecutive cycles.

In severe premenstrual syndrome, the drug is prescribed on the fourteenth day of the cycle at a dose of 1.25 mg. Before the onset of menstruation, the amount of the drug is gradually increased to five mg per day.

When is the remedy applied?

"Bromocriptine" is used when patients have the following indications:

  • the appearance of defects of the menstrual cycle, as well as infertility,
  • the development of hormone-dependent diseases and conditions accompanied (or not) by the occurrence of hyperprolactinemia,
  • the appearance of oligomenorrhea,
  • during the deficiency phase of lutein,
  • secondary-type hyperprolactinemia, triggered by the use of certain medication groups (antihypertensive drugs, psychostimulants, etc.),
  • the emergence of female infertility prolactin-independent nature,
  • development of polycystic ovary syndrome,
  • treatment of premenstrual syndrome (if there are painful sensations in the breast, psycho-emotional defects, flatulence, edema),
  • the development of male hyperprolactinemia and prolactin-dependent hypogonadism (with impotence, oligospermia, lack of sexual desire),
  • in the process of preparing for surgery, with the aim of reducing the size of the tumor,
  • in the postoperative treatment of increased prolactin levels,
  • in the process of treatment of a conservative type by prolactin: pituitary micro- and macroadenomas,
  • treatment of acromegaly complex
  • lactation inhibition: after an abortion or childbirth, during postpartum coarsening of the mammary glands and the first signs of mastitis,
  • diseases of the mammary glands of benign nature, mastalgia,
  • at all stages of Parkinson's disease (as in monotherapy, and as part of a comprehensive treatment),
  • for the treatment of anovulatory cycles in combination with anti-estrogen drugs,
  • for the treatment of cystic and nodal changes of a benign nature: with cystic and diffuse mastopathy.

Carefully

With caution, you can prescribe the drug for parkinsonism, which is accompanied by signs of dementia.

The drug has a calming effect on the central nervous system, as a result of which it becomes impossible to use it in its activities by those patients whose work requires a high concentration and control of various transport mechanisms.

Judging by the reviews, "Bromocriptine" causes drowsiness in many people.

Use during pregnancy

Patients who have reached childbearing age should be aware of the fact that the use of non-hormonal contraceptive methods is required when taking Bromocriptine. If there is a pregnancy that the woman intends to maintain, you need to abandon the use of this drug. The specialist may advise to continue the course of treatment only when the potential benefit is significantly higher than the potential risk.

When used during the first month and a half of gestation of the fetus, no adverse effects on pregnancy and childbirth were recorded. But still, Bromocriptine has side effects.

If the pregnancy develops in the patient who has a history of pituitary adenoma, you should stop taking the drug. After this, it is necessary to monitor the adenoma during the entire period of the child's bearing and constantly analyze the visual fields. With an increase in prolactinoma, you may need to re-take "Bromocriptine" in the dosage prescribed by the doctor.

Application features

In the process of treatment of mastitis drug must be used simultaneously with antibacterial agents. During the treatment of menstrual disorders, it is best to use the drug for several cycles. In these cases, reviews of "Bromocriptine" interest many.

If the disease is not characterized by an increase in the level of prolactin, the drug should be used in the minimum, but at the same time, with the proper effect of the dosage. It is selected directly by the attending physician.

The drug is taken by the patient with food. If the dose has been exceeded, such adverse reactions as headaches, drowsiness, psychomotor overexcitement, low blood pressure, hallucinations may be noted. During therapy, the use of Metoclopramide may be necessary. How to take "Bromocriptine", you must check with your doctor.

Some recommendations

Before the start of treatment of diseases of the mammary glands, it is necessary to exclude the presence of malignant tumors in the patient. When using the drug "Bromocriptine" as a means of suppressing lactation in the period after childbirth, you must always monitor your blood pressure level during the week of taking the medicine. If blood pressure rises (this happens along with severe headache and visual impairment), then you should immediately cancel the application and consult a doctor.

If this drug is required in the treatment of patients with acromegaly, gastric ulcer disease in history, you should immediately notify the doctor if intestinal and gastric disorders are observed.

When a patient develops mental disorders, the use of the drug in high doses requires special care.

In addition, all those taking this drug should be aware of the need for careful oral hygiene. If dryness of the mucous in this area is observed for more than two weeks, then it is necessary to discuss this issue with your doctor.

In the course of treatment of Parkinson's disease, it is necessary to systematically examine the condition of the liver, the heart system and blood vessels, the kidneys, and a blood test. If any irregularities are found, the use of this drug should be discontinued.

Judging by the reviews, "Bromocriptine" may precipitate. In this regard, the medicine should be stored in a cool place, which is reliably protected from direct sunlight.

Interaction with other drugs

You can not use "Bromocriptine" to stop lactation with other ergot derivatives. With concurrent administration with erythromycin, an increase in the concentration of bromocriptine in the blood plasma is traced. Combined use with furazolidone, selegilin, MAO inhibitors, procarbazine, methyldopa, ergot alkaloids, reserpine increases the risk of negative side effects. Such combinations of drugs are not recommended. It is necessary to inform the doctor about which drugs will be used (or used earlier) at the same time as Bromocriptine.

The drug reduces the effectiveness of oral contraceptives.

If ritonavir is used along with bromocriptine, the dosage of the first must be halved.

Can I drink alcohol?

Bromocriptine and alcohol are incompatible. Taking it along with ethanol can cause such reactions as hyperemia, vomiting, tachycardia, painful sensations in the chest, nausea, throbbing headache, cough, convulsions, weakness, a decrease in the clarity of vision.

Bromocriptine: Price

The cost of the drug will depend on the region and the pharmacy chain, but on average in Russia it starts at 200 rubles.

Analogues of "Bromocriptine" are the following drugs:

Analogs "Bromocriptine" interest many. If there is a need for replacement, you must first consult with your doctor, because when switching from one agent to another, you may need to clarify the dosage.

Many people wonder if bromocriptine is hormonal or not. Yes, this drug is hormonal in its action. Reviews confirm that the main feature when using it is a noticeable manifestation of side effects. A number of patients note this even with small dosages of the drug. There are cases when negative reactions occur only on the first day, and in the future are not too worried. Thus, you need to be very careful during the period of use of the medication, to monitor their condition and not to exceed the recommended dose in any case.

According to reviews, "Bromokreptin" quickly stops lactation, eliminates the unpleasant sensations in the ICP. And if there are adverse reactions, the drug can be replaced by an analog.

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