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Suspension Biseptol for the treatment of children from 2 months: instructions for use, the pros and cons of the drug

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One of the most famous and controversial antibacterial drugs sold in Russia is Biseptol. In the 80-90s of the last century, Biseptol was at the peak of popularity. The drug was prescribed by doctors of all specializations, ranging from the district pediatrician and ending with a narrow urologist. Patients, having felt the effectiveness of the remedy, perceived it as a panacea for all ills. If at first we still did not risk buying Biseptol without a doctor's prescription, then soon such a “trifle” as the recommendation of a specialist began to seem unnecessary. In Biseptole, they saw a panacea for any infection and took it almost uncontrollably for any reason, not excluding a banal cold.

Meanwhile, any antibacterial drug is not so harmless at all. And many ardent fans of Biseptol saw this, unfortunately, from their own experience.

The modern pharmaceutical market offers a large number of safer and more effective antibacterial drugs. The sales and popularity of Biseptol is shaken. However, until now, therapists and pediatricians write the long-memorized words Tab.Biseptoli in recipes. And still, in our pharmacies, they can sell Biseptol on the recommendation of not a doctor, but a friend, neighbor, or a complete stranger who gave advice in the queue for bread.

In this article we will try to highlight the positive and negative aspects of the drug and answer the main questions: is Biseptol safe? Should I take this medicine uncontrollably and what is it fraught with?

The composition and release form Biseptola

Few people know that the name hides in itself both the composition and the action of Biseptol. The particle “bi” originated from the Latin prefix “bis” - twice - and means that two components are included in the composition. The second part of the name - "septol" - apparently originated from the Latin "septicus", literally meaning "rotting." In the pharmaceutical industry, drugs that have the root “septol” in their names belong to the group of antiseptics.

So, what are the active ingredients that make up Biseptol? In the instructions for use of the drug, it is noted that Biseptol tablets is a combined agent consisting of two components: sulfamethoxazole at a dose of 400 mg and trimethoprim in an amount of 80 mg. The number indicated in the patented name "Biseptol 480" means nothing more than the total mass of the active ingredients of the preparation.

The pharmaceutical industry produces four main forms of release:

  • Biseptol 480 mg - tablets for adults,
  • Biseptol 120 mg - tablets for children,
  • Biseptol 240 mg - suspension for children. In 5 ml of the drug contains 240 mg of the combination of sulfomethoxazole and trimethoprim,
  • Option 480 mg - ampoules containing a concentrate from which solutions for infusions are prepared - intravenous drip injections, or more simply, droppers. Biseptol in ampoules is indicated for use in the hospital.

Some manufacturers have developed a Biseptol syrup release for children containing 240 mg of active ingredients.

The most popular forms of release, which most often have to deal with doctors and their patients, are Biseptol 480 mg in the form of tablets and Biseptol 240 mg suspension for children.

Composition, active ingredients

100 ml of the drug contains 4 grams of sulfamethoxazole and 0.8 grams of trimethoprim. These substances are the main therapeutic components of the drug.

Auxiliary ingredients medicinal product:

  • magnesium aluminum silicate,

methylhydroxybenzoate (preservative E 218),

propylhydroxybenzoate (preservative E 214),

maltitol (food additive E 965),

sodium hydrogen phosphate dodecahydrate,

Description and release form

Suspension is in a dark glass bottle.covered with a plastic screw cap. The volume of the bottle is 80 ml. A transparent plastic cup is put on the lid, intended for the dosage of the preparation.

Detailed instructions are attached to the suspension bottle. from manufacturers of the drug. The bottle and the instruction are placed in a cardboard box.

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When prescribed

Biseptol treats many infectious inflammatory diseases of the lungs. (pneumonia, including fungal) and bronchi (acute bronchitis), genital organs, ears, nose, larynx and throat, stomach, intestines (in particular, "travelers' diarrhea", typhoid fever, paratyphoid fever).

In combination with other means solution used in the treatment of cholera. This drug may be indicated for brucellosis, toxoplasmosis, and a number of other diseases.

Contraindications

According to the instructions for use, suspension Biseptol for children is not prescribed, if identified the following diseases:

  • liver failure,

some types of anemia and blood disorders

  • one of the drugs for arrhythmia, dofetilide, is prescribed.
  • The drug is not prescribed to infants younger than 2 months., it cannot be drunk in case of hypersensitivity to the main or auxiliary ingredients of Biseptol.

    Under the careful supervision of a pediatrician Biseptol can treat children with asthma, thyroid disease, some hereditary diseases.

    How and after what time does the medicine work

    The main components of the drug affect a large group of pathogens. The main component of the drug is sulfametaxosol.. Trimethoprim strengthens and strengthens its action.

    Both substances affect bacteria, and they stop producing folic acid, which is necessary for the formation of their DNA. As a result, the reproduction of microorganisms stops, and over time they die.

    In this way, sulfamethoxazole and trimethoprim have a bacteriostatic effect on microbes.

    If you stop taking the suspension after a couple of days, the bacteria will continue to multiply., and the therapeutic effect will be reduced to zero. Therefore, the drug is taken in courses, the duration of treatment is determined by the doctor.

    Dosage and frequency of administration at different ages

    The drug is prescribed to kids from 2 months of life.. The exceptions are children born to HIV-infected mothers. They doctor can prescribe suspension Biseptol from six weeks of age.

    When selecting the required dose of the solution is calculatedthat for the day in the body should receive 36 mg of the drug per kilogram of weight.

    On this basis, in the instructions for use of the drug The following approximate dosage is given.:

    • for children from 2 to 5 months - 120 mg per reception,

    for children from 6 months to 5 years - 240 mg per reception,

    for children from 6 to 12 years old - 480 mg per reception,

  • for children over 12 years old the medicine is dosed in the same way as for adults - 960 mg per reception.
  • The medicine is taken twice a day, after 12 hours.. In case of a complicated course of an infectious disease, doses may be increased by a doctor.

    The longer the treatment, the smaller single dose will be prescribed by the pediatrician. Depending on the type, form and severity of the disease the duration of the course is from 5-7 days to 3 months.

    How to take special instructions

    Suspension taken by mouth., for the exact dosage of the medicine a measuring cup is used, which is put on the lid of the bottle.

    If any adverse or allergic reactions appear, stop the treatment and contact your pediatrician.

    Biseptol is prescribed when the expected therapeutic effect from its effect exceeds the risks from the likely side effects.

    The attending physician, when prescribing single doses, takes into account the geographical location of the region, since bacteria can be active in different places in different ways.

    With prolonged treatment, the pediatrician should monitor the composition of the blood and urine of the child., especially if he had previously been diagnosed with renal failure.

    With long courses of drug manufacturers recommend folic acid intake.

    You need to drink a lot during treatment., as water prevents the formation of crystals in the urine (prevention of crystalluria).

    The duration of the course should be as short as possible, but at the same time sufficient for treatment.

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    Interaction with other drugs

    Biseptol may enhance the effect of some drugs and reduce the effect of taking others.

    Only the attending physician can know all the subtleties of drug compatibility, therefore Biseptol should never be used for self-medication..

    Suspension can be taken along with some antibiotics, antivirals, painkillers and antipyretics (paracetamol and ibuprofen).

    Biseptol enhances the effect of a number of drugs, necessary for diabetes, and indirect anticoagulants (substances that prevent thrombosis). The drug also enhances the effect and toxic effect of phenytoin (drugs for epilepsy).

    Dofetilide (drug used for arrhythmias), with Biseptol not prescribed. Taking the suspension together with pyrimethamine (a cure for malaria and toxoplasmosis) can lead to the development of one of the types of anemia.

    There is a large list of drugs with which Biseptol is prescribed with caution or not prescribed at all (these are, for example, diuretics and antidepressants).

    Overdose

    With an overdose of the drug the following conditions appear:

    stitching pains in intestines

    headache, depression,

    drowsiness or fever,

    hematuria (increase in the amount of blood in the urine),

  • crystalluria (the appearance of salt crystals in the urine).
  • With prolonged overdose observed:

    • thrombocytopenia (reduction in the number of platelets in the blood and bleeding),

    leukopenia (decrease in the number of leukocytes in the blood), megaloblastic anemia,

    If it turned out that overdose was allowed repeatedly, or some time has passed since the drug was taken, the doctor prescribes medications that reduce the effect of Biseptol.

    In severe cases a child may be assigned a blood purification procedure — hemodialysis.

    Side effects

    Side effects of the drug may occur in different ways.. If you are hypersensitive to the usual doses of medicine, children may experience the following symptoms:

    • allergic reaction: edema, skin rash, itching, redness of skin,

    headache, ringing in the ears and cramps, cough, shortness of breath,

    nausea, vomiting, stitching pains in the abdomen,

    changes in the composition of blood and urine, kidney disorders,

  • fever.
  • Need to say that the side effects of the medication at the dosage prescribed by the doctor are extremely rare.

    Prices in pharmacies in Russia

    Suspension Biseptol can be bought in almost all pharmacies in RussiaThis medicine can be ordered online in pharmacy chains.

    The cost of the drug in pharmacies Moscow ranges from 119 to 124 rubles per bottle, St. Petersburg - from 122 to 134 rubles, in Krasnoyarsk, Abakan, Novosibirsk and Irkutsk the drug costs 122 - 140 rubles, in Vladivostok and Khabarovsk - 111-136 rubles, in Rostov-on-Don Don and Perm - 122-128 rubles.

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    Storage conditions and leave, shelf life

    The drug, according to the instructions, sold by prescription. But many private pharmacies and online stores offer to buy it without a prescription.

    Store the medicine in a dark place, the storage temperature should be no more than 25 °.

    Closed, unpacked medication can be stored for three years from the date of issue. About the time of use of Biseptol after opening the bottle in the instructions says nothing.

    Yana: “My baby Masha is only two months old, she had cold symptoms, and then she started coughing. The doctor prescribed Biseptol.

    Doubted its effectiveness, but the cough quickly passed. The instruction to the drug is very detailed, although it was not written for patients, but for doctors (there are a lot of incomprehensible terms). ”

    Ira: “My son's ear ached - the doctor made a diagnosis of otitis media,” and among other medications prescribed Biseptolum solution. Ear pains stopped on the third day.

    The medicine is easy to dose with a special cork-cap, the suspension has a pleasant strawberry flavor. And she helps well! ”

    Yuliya: “The child was three years old, there was a severe cold, our pediatrician was afraid of complications and pneumonia, prescribed Biseptol in suspension. The illness proceeded with cough and fever. She gave the potion seven days, everything went. We are lucky, there are no complications after ARVI. ”

    Nina: “My daughter is 7 years old, in the summer during a hike we got wet and froze. Masha started strong ciscitis. The doctor prescribed a suspension Biseptol.

    The syrup tastes sweet, but not cloying, the child drinks with pleasure. Now the worst is over, but the treatment will take ten days, probably drink the whole bottle! ”

    Anastasia: “My daughter (9 years old) had tracheitis. Biseptol was discharged to her in combination with cough syrup. The cough stopped, but it is difficult to say which of the drugs helped more. Confused by the large list of side effects in the instructions. ”

    Pediatric doctors often prescribe it. for the treatment of uncomplicated inflammatory and infectious diseases.

    Description of the drug and its characteristics

    The drug "Biseptol" (suspension) is available in vials of 80 milliliters. The active ingredient of the drug is sulfamethoxazole and trimethoprin. The content of these components is 200 and 40 milligrams, respectively, for every 5 milliliters of medication. The tool also contains additional substances, including flavors. A feature of the drug is the complete absence of sugar in it.

    The cost of the drug depends on where to buy it. "Biseptol" (suspension) will cost you about 130 rubles. Tablets with the same name are even cheaper. Please note that capsules are available in different dosages.

    Substitutes and relative analogues

    Has "Biseptol" (suspension) analogues. They can be complete or relative. If you look for medicines with the same active ingredient, then you should pay attention to the drugs "Bactrim", "Grossptol", "Co-Trimoxazole", "Oriprim", "Tsiplim" and many others.

    Also, in an indirect degree, “Amoxiclav”, “Supraks”, “Sumamed”, “Azitrus” and others can be attributed to the drug substitutes. These drugs have a different composition and distinctive active ingredients. However, they are antibiotics and are characterized by the same indications for use.

    Prescription drug

    The drug "Biseptol" (suspension) should be appointed by a specialist after carrying out the necessary laboratory tests. Independent use of the drug is unacceptable. Otherwise, the wrong approach to treatment can lead to the fact that microbes will develop resistance to the specified active substance. Instructions for use suggests that the drug "Biseptol" (suspension) is prescribed for the following indications:

    • diseases of the lower respiratory tract (bronchitis, pneumonia),
    • pathologies of upper respiratory tract (otitis, tonsillitis, antritis),
    • urinary tract infections,
    • diarrhea caused by the multiplication of bacteria
    • other bacterial infections caused by susceptible microorganisms.

    Suspension: instructions for use for children

    The drug is intended for oral use. The drug has a pleasant taste, so does not require additional sweetening or dilution with water. The drug "Biseptol" (suspension) is prescribed in accordance with the age of the child. Before use, be sure to shake the medicine in the bottle. After taking let your baby drink the suspension. It is necessary that the remnants of the active substance is not settled on the mucous membranes of the oral cavity.

    The medication is prescribed in the amount of 200 mg of sulfamethoxazole and 40 mg of trimetoprin for each kilogram of body weight. In case of a severe infection, it is permissible to double the indicated amount of the medicine. Instructions for use recommends taking the drug in the following dosages:

    • in the first 6 months - 2.5 ml,
    • from 7 months to 3 years - 5 ml,
    • from 4 to 6 years - 5-10 ml
    • from 7 to 12 years old - 10 ml.

    After 12 years of the drug "Biseptol" (suspension), the use is the same as for adults. Provided that the child’s body weight is not less than 40 kilograms. The dose is prescribed from 20 to 30 milliliters, depending on the severity of the infection. The drug is taken twice a day at regular intervals (12 hours).

    Duration of therapy

    How long does Biseptol (suspension for children) take? The instruction recommends using the medicine in a strictly prescribed dose for at least five days.Even if it became much easier for the child after 2-3 days, it is not advisable to cancel the medication. As you may have already learned, this can lead to the establishment of microbial resistance.

    For acute infections, the medication is usually prescribed for 5-7 days. If after this time the patient does not feel better, then it is worth reviewing the therapy. Perhaps it is this medication that is not suitable, and therefore it is necessary to choose an analogue based on another active ingredient. When urinary infections in a child suspension is prescribed for 2-3 weeks. Treatment of ENT diseases is carried out for 10 days.

    Adverse reactions to therapy

    In some cases, the drug Biseptol (suspension for children) has a negative effect. The instruction contains information about side effects. With proper use and compliance with the above doses, they occur very rarely. However, all consumers should be aware of them and in case of those, contact the specialists.

    The drug may affect the functioning of the nervous system. This causes a headache, impaired consciousness, depression, tinnitus, increased nervousness. The drug for oral use can lead to nausea, diarrhea, abdominal pain. Less common constipation, a violation of taste. In the presence of a history of renal diseases, their exacerbation occurs.

    Separately, it should be said about allergic reactions to the components of the drug. They develop more often than the above described adverse reactions. Any such symptoms may be urticaria, tinnitus, itching, sneezing. In severe cases, edema occurs. There are cases of increased body temperature during the use of the drug. This reaction is indirectly attributed to allergic. However, doctors do not always cancel therapy.

    The interaction of drugs with other drugs: features of use

    Often prescribed in combination with other drugs, the drug Biseptol for children (suspension). Instructions for use allow similar combination. However, some drugs are prohibited to take at the same time.

    Often, childhood diseases are accompanied by fever. More often, paracetamol-based and ibuprofen-based medications are used to eliminate fever and relieve pain. They go well with the described drug. Immunomodulators based on antiviral agents may also be used. With the simultaneous use of sorbents is to take a break between drugs for at least 2-3 hours.

    Do not combine medication with diuretics, antidepressants and other antibiotics. If necessary, such therapy should first consult with your doctor. The doctor will be able to correctly adjust the dosage of one or another remedy, since Biseptol affects the effectiveness of the described medicines.

    Additional information about the drug

    The drug "Biseptol" (suspension for children) has the advantage in the majority of good. There are negative opinions about the tool. However, they are less common.

    The drug "Biseptol" is released from pharmacies exclusively by prescription from a doctor. If you didn’t ask for it when you bought the train, then know that this network violates the law. The drug is stored no more than three years from the date of manufacture. The ambient temperature should not exceed 25 degrees. Do not take medicine after the expiration date. This can lead to a completely unexpected reaction of the body and serious consequences.

    "Biseptol" (suspension): reviews of people who had experience with the use of drugs, and doctors

    What are the opinions of consumers about medicine and doctors? Let's try to understand this issue.

    Specialists rarely prescribe the described medication. Doctors say that it can negatively affect the work of the child's body. In modern pharmacology, there are safer, with no less effective formulations. Pediatricians recommend taking medication only in exceptional cases.

    Consumers have different opinions about the drug "Biseptol." Some patients say that it is very effective. Improvement occurs after a few days of use. The drug is actively fighting bacteria, blocking their reproduction. Despite this positive action, the tool should be used strictly according to the instructions and not less than five days. The advantage of the medication is that it has the form of a suspension. The medicine can be easily given to the child. Syrup has a pleasant strawberry flavor.

    Most patients experience problems with the digestive system during therapy. This symptom is especially pronounced in children. According to doctors, this reaction is absolutely normal. After all, medicine is an antibiotic. It kills not only pathogenic bacteria, but also affects normal microflora. Experts recommend immediately after the end of therapy to take reducing drugs. This is a complex of beneficial bacteria, vitamins and trace elements. Such funds will help the child recover faster from the disease and increase the body's immune defense.

    Almost all consumers note the low price of medication. Many similar drugs and substitutes cost several times more. This fact can be called an undoubted advantage of the drug. After all, the consumer is always seeking to save. Also, users say that one bubble is not enough for one course of treatment. Much depends on the age of the child. If you give your baby 5 milliliters of suspension per day, then in 5 days you only use a third of the vial. With a maximum dose of 20 milliliters of the drug is not enough even for a course of treatment. Pay attention to this when getting a recipe. Since that is where the doctor indicates the amount of the necessary funds. A pharmacist will sell you a strictly limited amount of the drug.

    Some patients report an increase in body temperature during treatment. Experts sometimes call this reaction normal. After the use of the drug begins the massive death of germs and bacteria in the body. All this is marked by intoxication, which is often accompanied by fever. If the body temperature does not drop and lasts for three days or more, then this is the reason for the withdrawal of the funds and the selection of its substitute. In any case, do not make independent decisions. Talk to doctors for advice. It is especially important to follow the recommendations of the doctor when it comes to the health of the child. After all, any wrong action on your part or self-prescribing a drug can lead to unpleasant and serious consequences. Remember this always.

    To summarize: the conclusion of the article

    You have learned about the antibacterial prescription drug "Biseptol". Instructions for use (suspension), reviews were presented to your attention. Remember that this medicine is never prescribed for prophylaxis. It is used exclusively for bacterial infection. The drug is powerless in the fight against a viral or fungal infection.

    The dosage of the Biseptol medication should be chosen strictly in accordance with the patient’s body weight and age. Otherwise, you may experience an overdose of the drug. If you detect side reactions, you should immediately contact the experts for help. Good health to you, do not get sick!

    Release form and composition

    Biseptol is available in the form of tablets and suspensions. Suspension is available in a volume of 80 ml, in a bottle of dark glass. The manufacturer of the drug Medana Pharma TERPOL Group J.S., Co, Poland.

    The composition of 5 ml suspension includes:

    • sulfamethoxazole - 200 mg,
    • Trimethoprim - 40 mg,
    • various excipients.

    The medicine belongs to antimicrobial agents, it is made from chemical raw materials, it is released by prescription.

    Indications for use

    Indications for use Biseptola is caused by bacteria and protozoa infections or fungal infections from:

    • respiratory system: bronchitis, empyema, pulmonary abscess, pneumonia, bronchiectasis,
    • urinary system: inflammation of the urethra, cystitis, pyelitis, pyelonephritis,
    • male reproductive system: prostatitis, inflammation of the appendages of the testicles,
    • genital tract: gonorrhea, chancroid, venereal inguinal and lymphogranuloma,
    • digestive tract: bacterial diarrhea, shigellosis, cholera, typhoid fever and paratyphoid fever, inflammation of the mucous membrane of the stomach and intestines,
    • liver and gallbladder: inflammation of the gallbladder, cholangitis,
    • skin and soft tissues: acne, boils, pyoderma, erysipelas, infected wounds and suppurations,
    • ENT organs: otitis media, sinusitis, laryngitis,
    • nervous system: inflammation of the membranes or abscess of the brain,
    • other: septicemia, brucellosis, blastomycosis, malaria, toxoplasmosis.

    Mode of application

    Suspension is taken after eating inside. It does not contain sugar, has a pleasant strawberry flavor.

    For the treatment of infection in adults and children from 12 years of age, receive a suspension of 20 ml every 12 hours, with severe infections, the dose can be increased to 30 ml. The average course of treatment is from 10 to 14 days.

    Infants from 1.5-2 to 5 months are given 2.5 ml each, from 6 months to 5 years old - 5 ml each, from 6 to 12 years old - 10 ml every 12 hours.

    The drug should be administered exclusively by a doctor due to the presence of a large number of possible side effects. Depending on the type of pathogen and the severity of the infection process, the dosage and duration of administration may vary at the discretion of the physician.

    special instructions

    • with a lack of folate or a tendency to hypersensitivity reactions, Biseptol must be used with caution,
    • With prolonged therapy, careful monitoring of the state of the blood is necessary,
    • in old age or suspicion of folate deficiency even before the start of treatment, it is necessary to use the drug very carefully,
    • when conducting long-term therapy or prescribing the drug in high doses, folic acid preparations can be used,
    • the likelihood of an adverse effect of the antibiotic increases when the excretory function of the kidneys and bladder is disturbed,
    • against the background of the use of the drug, it is not recommended to use certain products that may reduce its effectiveness, for example, cauliflower, beans, spinach, as well as tomato and carrots,
    • it is not recommended to be much in the sun and under ultraviolet rays,
    • in patients with acquired immunodeficiency syndrome, the occurrence of side effects is more likely,
    • It is not advisable to prescribe a drug for inflammation of the tonsils or pharyngeal mucosa with lesions of certain types of streptococci, since its strains have a high resistance to Biseptol.

    Drug interactions

    • with simultaneous use with some diuretic drugs may decrease blood platelets, which increases the tendency to bleeding,
    • when using anticoagulants, hypoglycemic agents and methotrexate, Biseptol increases their effectiveness,
    • local anesthetics and other substances involved in the synthesis of PABK reduce the effect of the antibiotic,
    • Phenytoin and barbituric acid derivatives increase folate deficiency,
    • salicylates enhance the antibacterial effect of Biseptol,
    • Vitamin C and other urine acidity agents increase the risk of increased salt levels in the urine,
    • elderly patients may experience an increase in the content of digoxin in the blood serum,
    • hypocholesterolemic agents (colestiramine) reduce the absorption of the antibiotic,
    • the drug reduces the hormonal activity of oral contraceptives, and therefore their effectiveness decreases.

    Analogs suspension Biseptol

    Co-trimoxazole preparations are widely available in the form of tablets, more rarely in dosage form for infusion solutions and syrup. Analogs of Biseptol in the form of a suspension:

    • Bactrim - has a similar dosage, composition and indications, has a pleasant banana flavor. Manufacturer: ICN Jugoslavija (Yugoslavia),
    • Berlotsid - analogue of the German manufacturer, Berlin-Chemie,
    • Co-trimoxazole, Pharmstandard-Leksredstva (Russia),
    • Co-trimoxazole, Rivopharm (Switzerland),
    • Oriprim, Cadila Healthcare (India),
    • Septrim, Glaxo Wellcome Operations (UK).

    How Biseptol works - pharmacological action

    Sulfamethoxazole is the main component of Biseptol, which has a rather strong bactericidal effect. It disrupts the synthesis of dihydrofolic acid, essential microorganisms for vital activity. Trimethoprim enhances the action of sulfomethoxazole. Synergy, that is, the summation of the effects of the Biseptol components, was first described in the late 60s.

    The ratio in which the components are dosed is precisely calibrated. If in a Biseptol tablet, it is about one to five, then when absorbed into the blood, the ratio of sulfamethoxazole and trimethoprim drops to one in twenty. These concentrations are necessary for the peak, maximum synergistic effect of the components.

    Does Biseptol have any relation to antibiotics or not?

    This question so often excites patients that it is simply necessary to dot the i. So, an antibiotic is a medicinal substance of natural (animal, vegetable or microbial origin), which has an antibacterial effect that completely inhibits the growth and reproduction of bacteria. The modern pharmaceutical industry also produces semi-synthetic antibiotics.

    A careful study of the instructions for Biseptolum makes it obvious that its components have nothing to do with antibiotics. Both substances that are part of the drug, synthesized in the laboratory. Sulfamethoxazole belongs to the group of sulfanilamide drugs, and trimethoprim is used exclusively to enhance the effect of the main component.

    So, the answer to the question whether Biseptol belongs to antibiotics or not is unequivocal and not subject to doubt. Biseptol is a sulfonamide drug that has an antibacterial effect. But not an antibiotic.

    However, it is naive to believe that a remedy that is not related to the notorious “harmful” antibiotics is as safe as multicolored sweet vitamins. Sulfonamides are also serious drugs that must be taken exclusively under the supervision of a physician. Otherwise, you can wait for not quite pleasant consequences, including the formation of microorganisms resistant to drugs. After all, it is no wonder that all antibacterial agents — antibiotics, sulfonamides, and representatives of other pharmacological groups — belong to prescription drugs. And do not forget about it.

    Biseptol: indications for use

    The answer to a common and seemingly simple question, from which Biseptol helps all the same, cannot be unequivocal. After all, the combination of sulfamethoxazole and trimethoprim is a serious drug, the selection of which requires careful information collection. Ideal if this is a specialist. Let's try to figure out in which cases Biseptol is the drug of choice and when it is better to prefer it to another medicine.

    The main indications for Biseptol are, of course, diseases caused by pathogenic microorganisms. The spectrum of action of the sulfamethoxazole-trimethoprim complex is quite wide and includes the most diverse gram-positive, gram-negative bacteria, protozoa, and even pathogenic fungi. Streptococci, staphylococcus, Escherichia coli, Salmonella, Chlamydia, Toxoplasma and other microorganisms are exposed to the bactericidal effect of the drug. Tubercle bacillus, treponema, leptospira, pathogenic viruses are resistant against Biseptol.

    A sufficiently wide range of microorganisms sensitive to Biseptol provides the same extensive list of diseases for which the medicine is used. Let's try to figure out when this drug is prescribed.

    The most common gram-positive bacteria that usually cause diseases of the upper and lower respiratory tract are staphylococci and streptococci. The high efficiency of Biseptol against these microorganisms makes it possible to successfully use it for bacterial pharyngitis and tonsillitis - sore throat.

    Biseptol also has positive results in bacterial bronchitis. However, it should be noted that bronchial inflammation is often caused by viruses that are resistant to the action of antibacterial drugs. Therefore, be prudent: when cough appears, you should not drink such products without a doctor's recommendation.

    Inflammation of the maxillary sinuses - sinusitis - most often cause all the same cocci, less often - chlamydia, mycoplasma and viruses. Despite the fact that antibiotics are the drugs of choice for antritis, sometimes Biseptol is still prescribed.

    Is the treatment of intestinal infections justified?

    The activity of the drug against E. coli allows the use of Biseptol for acute intestinal infections. It is important that the effect of the drug extends to enterotoxigenic strains of the pathogen. Enterotoxigenic Escherichia coli is responsible for severe bloody diarrhea, which is accompanied by general intoxication of the body. In addition, there is an experience of using the drug for salmonellosis.

    Однако, прежде чем принять решение об использовании любого антибактериального средства при кишечных инфекциях, следует вспомнить один важный нюанс. Все возбудители этих заболеваний элиминируются самостоятельно в течение недели. Говоря понятным языком, через неделю после заражения болезнь прекратится без всякого лечения. This also applies to the notorious salmonellosis, a diagnosis of which sometimes leads the patient and his relatives to a state of panic.

    Standard protocols for the treatment of acute intestinal infections do not involve the use of any antibacterial drugs. The basis of the treatment of such diseases is to ensure sufficient fluid intake.

    In severe cases (for example, with the development of infection in young children or the elderly, in patients with weakened immunity), it is still possible to prescribe antibacterial drugs. Again, Biseptol is not the gold standard in such cases - there are many other, safer drugs. For example, funds from the group of nitrofurans are not absorbed into the blood. The efficacy and safety of these drugs is based on the fact that they work only in the intestinal lumen.

    Therefore, in the overwhelming majority of cases, Biseptolum treatment of intestinal infections is completely unjustified.

    Before continuing reading: If you are looking for an effective method of getting rid of a cold, pharyngitis, tonsillitis, bronchitis or colds, then be sure to take a look at this section of the site after reading this article. This information has helped so many people, we hope will help you too! So, now back to the article.

    Urinary tract infections

    E. coli is recognized as the most common cause of urinary tract infections. Approximately 80% of all inflammatory processes in the bladder are caused by this pathogen. Therefore, Biseptol, which is active against Escherichia coli, in some cases gives good results for cystitis.

    However, it should be remembered that the drug of choice for urinary tract diseases is still the fluoroquinolone antibiotic. It is impossible to treat these pathologies carelessly: with inadequate therapy, there is a fairly high risk of chronicity of the pathological process. Untreated cystitis threatens chronic inflammation of the bladder, which is difficult to treat.

    What is the danger of uncontrolled use of Biseptol in cystitis? In fact, everything is very simple: the frequent use of Biseptol for a long time led to the gradual emergence of resistance to the components of the drug. As a result, the effectiveness of the drug has decreased significantly.

    In the treatment of many infections, the relief received at the beginning is accepted by the patient for complete healing. In fact, with the uncontrolled use of Biseptol, and other antibacterial drugs, there is a possibility that some particularly resistant microorganisms survived. With such a development of events, the disease enters a latent chronic phase. Chronic cystitis may not manifest itself for some time, and this is its particular danger.

    Therefore, it is not worth the risk. Cystitis and other diseases of the urinary tract should be treated by a doctor, and uncontrolled intake of Biseptol with these pathologies may be fraught with complications.

    Biseptol for colds: necessary, contraindicated or useless?

    One of the most common misconceptions of Russian patients is blind faith in the mighty power of antibiotics in any disease. It is impossible to link this confidence with objective reasons. Our citizens stubbornly want to treat flu, colds and ARVI with antibiotics. The worst thing is that often caring mothers spend these experiments with their children.

    So, let's try to understand this, of course, an important issue. Do I need antibacterial drugs, to which Biseptol belongs, with a cold or ARVI?

    To do this, first of all, you need to remember that cold, flu, and an acute viral disease - ARVI - are caused by various viruses. And from the instructions for use of Biseptol we know that this drug, like any other antibacterial agents, does not affect viruses. Absolutely. Thus, applying it to a cold, we will not get any effect. In addition to the side.

    The common cold or SARS normally goes away on its own within a week or a little more. However, weakened patients, young children, elderly patients - all those who have malfunctions in the immune system - the disease can take a protracted course. This leads to a complication of pathology and the additional infection by bacteria. In such cases, as a rule, an antibacterial drug is needed. And the use of Biseptol tablets will be very appropriate.

    How to notice this line between viral and already complicated viral-bacterial infection? For a person far from medicine, it really is not so simple. One of the symptoms of a complicated viral disease is a sharp deterioration. For example, a significant increase in temperature after a few days of illness and a period of relative calm. At the same time, the fever either does not stop at all, or after taking antipyretic drugs, the temperature drops very slowly and not for long. On the complication of infection may indicate the appearance of a strong cough, accompanied by sputum discharge. The treatment of a cold with a bacterial infection should be handled by a doctor who will select the correct antibacterial drug.

    Recommended dosages

    According to the instructions for Biseptol, the course of treatment is chosen individually for each patient.

    For children, the drug is prescribed starting at 6 weeks of age. Infants are usually prescribed a suspension or syrup. Most often, pharmacies sell Biseptolum suspension, the instructions for which clearly describe the recommended treatment regimen depending on the age of the child.

    The standard dosage of Biseptol for children from six months to five years is 240 mg twice a day. 240 mg of sulfamethoxazole and trimethoprim are contained in 5 ml of suspension or syrup, therefore, it is very convenient to dose the drug. Even if you lose the measuring spoon, which is usually attached to the medicine, problems with the reception will not arise. After all, a standard teaspoon contains exactly 5 ml of solution. One teaspoon of Biseptol syrup or suspension in the morning and evening is enough for the child to receive a daily dose of sulfamethoxazole and trimethoprim.

    If a child is able to swallow a pill, he is prescribed a tablet form of Biseptolum at a dose of 120 mg. Children under 5 take 2 tablets at once twice a day.

    Starting at the age of 6, the drug is prescribed at a dose of 480 mg twice a day, and it is most convenient to buy Biseptol tablets.

    Since the age of 12, Biseptol is discharged at a dose of 960 mg. Frequency of use - twice a day.

    The course of treatment is selected depending on individual factors and can be from 5 days to two weeks. In severe cases, the doctor may prescribe a dose that exceeds the standard recommended by 50%.

    Features of the use of suspensions

    I would like to draw attention to the peculiarities of receiving the Biseptol suspension. Usually, in the instructions for each suspension, the manufacturer tries to warn the patient to shake the vial before using the medication. And unfortunately, not everyone complies with this requirement. Why is it so important to finish reading the abstract to Biseptol to the end and not to forget to shake the bottle with the suspension?

    Any suspension is a two-fraction system in which the active substance is present in undissolved form. It is evenly distributed only after vigorous shaking. Otherwise, you risk drinking a teaspoon of a suspension containing not 240 mg of Biseptolum, but much less, and it is not possible to establish the exact mass.

    If you bought Biseptol syrup, you can safely give it to a child without prior manipulations with the bottle - the syrup is absolutely homogeneous.

    And finally. All children's forms of Biseptol - both syrup and suspension - have a pleasant taste. Children are usually happy to be treated with such "edible" drugs, so be careful and keep the drug out of the reach.

    Rules of admission, or How to drink Biseptol?

    Therapy with any medication should not be chaotic. If you have to drink antibiotics or sulfanilamide antibacterial drugs, you should be especially attentive to treatment. From compliance with the rules of admission depends on the effectiveness of the drug, and the likelihood of adverse events.

    So, how to drink Biseptol? You just need to remember the following rules:

    • Observe the 12-hour interval between doses. For example, the morning dose to drink at 8 am, and the evening - at 8 pm. Failure to comply with the regime threatens to reduce the antibacterial activity of Biseptol,
    • drink the drug (and pills, and suspension) should be exclusively after meals. Otherwise, the medicine irritates the stomach walls,
    • The minimum course of therapy should be at least five days. All lovers to be treated for three days must arm themselves with patience. Otherwise, you risk getting a complication of an infection that will be hard to resist antibiotic therapy.

    Side effect

    If you carefully read the instructions for Biseptol, the abundance of information about the side effects of the drug can shock even the most sophisticated reader. But in practice, things are not so threatening.

    As a rule, in recommended doses, both tablets and Biseptol suspension are well tolerated. The side effects that are reported most often do not usually require discontinuation of the drug. Among the most common adverse events I would like to note:

    • dermatological manifestations in the form of a rash and urticaria. Allergic reactions are more common in sensitized (sensitive) patients,
    • violation of the gastrointestinal tract: nausea, rarely - diarrhea, loss of appetite, stomatitis.

    With long-term intake of high doses of Biseptol, side effects may be more pronounced. Occasionally serious allergic reactions are recorded, candidiasis may develop due to changes in the composition of the intestinal microflora.

    I would like to reassure those patients who, having finished reading the abstract to Biseptolus to the section “Side Effects” and being horrified, make a responsible decision to treat with folk, rather than “harmful” medicine.

    The list of side effects includes all the symptoms that were recorded during the trials of the drug. The number of patients participating in clinical trials is usually several thousand people. Post-marketing tests last for the entire period of sales of the drug. Each patient is a potential participant in these studies, and the fact that a new side effect appears in him will be recorded in the abstract. Therefore, the likelihood of most side effects in the light of large numbers is extremely small. Thus, in the instructions for Biseptol, the possibility of hematopoietic disorders is described, but if the recommended doses are observed, this effect is observed only in one of several hundred patients.

    When does Biseptol not work?

    I would especially like to note that in case of angina caused by beta-hemolytic streptococcus, Biseptol is not recommended for use. The fact is that strains of hemolytic streptococcus group A are almost completely resistant to sulfanilamide agents. Over a long period of antibacterial therapy, microorganisms have been formed, on which sulfamethoxazole does not have a bactericidal effect.

    An error in the selection of the drug for tonsillitis can lead to complications, especially in young children. Therefore, the examination and consultation of a doctor is necessary: ​​it is only a specialist who can distinguish streptococcal sore throat from staphylococcus.

    The question of choice, or How to replace Biseptol?

    The pharmaceutical market is usually saturated with analogues that can fully replace the drug. Often it is difficult to understand the abundance of various drugs, even a doctor. A person who is not related to medicine, an excessive abundance of analogs or generics can be stumped. Let's try to figure out what can replace Biseptol in Russia.

    So, most often in pharmacies it is Biseptol that is sold in pills and children's suspension produced in Poland. A fairly common drug of the French company Senexi Bactrim is also not inferior in quality to the original remedy. The Russian company Pharmstandard produces a cheaper analogue of Biseptol in tablets and suspensions - Co-trimoxazole at a dose of 480 mg and 240 mg, respectively. Other Russian pharmaceutical companies also produce drugs with the same name. All of them differ in the democratic price.

    The rest of modern Biseptol analogues are extremely rare. Sometimes pharmacies offer very high-quality Dutch Bi-septin tablets (manufacturer NaturProduct) and Septrin, produced by the world-famous British concern Glaxo.

    Reviews Biseptol: do you need to believe them?

    Opinion about the drug, based on reviews of it, is a rather controversial way to evaluate a drug. After all, the indications for use, and efficacy, and side effects are purely individual. I would like to warn against the advice of non-specialists and random people. Taking medication only because it helped a neighbor (relative, acquaintance or not) can significantly aggravate the course of the disease. Canceling the drug due to someone's unflattering response can lead to the same sad consequences.

    Remember that patient reviews about the drug - a subjective assessment of a layman. And rely on them in any case.

    However, the opinion of experts on the drug can be very useful. Reviews of doctors about Biseptol, by the way, are rather contradictory. Many doctors prefer modern antibiotics, in spite of some love for Biseptol doctors of the older generation. This is primarily due to the persistence or addiction of many microorganisms to sulfamethoxazole. According to unverified data, about 70% of pathogenic bacteria are resistant to Biseptol.

    Some doctors emphasize a very eloquent fact. In standard treatment protocols, Biseptol is never the drug of choice. This means that in almost all cases there is a more correct or safe alternative to this medicine.

    But to the question what is better Biseptola, your doctor must answer.

    And the last thing I would like to say. Providing optimal storage conditions is simple - just put the medicine pack in a place protected from light. And, of course, take care of the inaccessibility for children.

    The article above and comments written by readers are for informational purposes only and do not call for self-treatment. Talk to a specialist about your own symptoms and illnesses. When treating with any medicinal product, you should always use the instructions in the package along with it, as well as the advice of your doctor, as the main guideline.

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    Want to get rid of your nose, throat, lung, and colds? Then be sure to take a look here.

    It is also worth paying attention to other drugs:

    Additional funds

    For suspension: purified water, macrogol, carmellose sodium, propylene glycol, propyl parahydroxybenzoate, aluminum-magnesium silicate, sodium saccharin, citric acid monohydrate, maltitol, sodium dodecahydrate phosphate, methyl parahydroxybenzoate.

    For tablets: propylene glycol, potato starch, methyl parahydroxybenzoate, talc, propyl parahydroxybenzoate, magnesium stearate, polyvinyl alcohol.

    Pharmacodynamics and pharmacokinetics

    Combined antimicrobial drug. The main active ingredient - Co-Trimoxazole (trimethoprim + sulfamethoxazole). What is it used for? Biseptol has a double blocking effect on the metabolism of bacteria. Trimethoprim has an inhibitory effect on the enzyme involved in folic acid metabolism, and turns dihydrofolate into tetrahydroflorate. Sulfamethoxazole has a bacteriostatic effect. In the complex, the components of the Biseptol preparation block the biosynthesis of purines and nucleic acids, without which the multiplication and growth of bacteria is impossible.

    Active substances are actively absorbed from the gastrointestinal tract. Excreted mainly through the kidneys.

    Operating principle

    The main components of Biseptol have an antimicrobial effect, affecting the formation of proteins in bacterial cells. Due to their influence, protein synthesis in microbial cells is disturbed, leading to their death. This effect is called bactericidal.

    The drug is effective against:

    • Intestinal sticks.
    • Hemophilic sticks.
    • Bacteria Haemophilus parainfluenzae.
    • Moraksell cataris.
    • Shigella.
    • Citrobacter
    • Klebsielle.
    • Hafnium.
    • Serratia.
    • Yersinia
    • Protea.
    • Enterobacter.
    • Cholera vibrio.
    • Edwardsiel.
    • Alcaligenes faecalis bacteria.
    • Burkholderia.

    Pneumocystas, Listeria, cyclospores, Brucella, Staphylococcus, Pneumococci, Providences, Salmonella and some other bacteria are also sensitive to Biseptol.

    Mycoplasma, pseudomonads, pale treponema and tubercle bacillus possess resistance to the drug. Не действует Бисептол на вирусы, поэтому такой медикамент не назначается при ОРВИ, о чем говорит и доктор Комаровский. Нечувствительными к лекарству бывают и микроорганизмы, на которые обычно Бисептол действует, поэтому лечение всегда рекомендуют начинать после анализа на чувствительность.

    Как отличить вирусную и бактериальную инфекции, расскажет Евгений Комаровский в видео:

    Бисептол обычно назначают:

    • With ENT infections - otitis media, sore throat, pharyngitis, laryngitis and others.
    • With bacterial infection of the respiratory tract, for example, with pneumonia or bronchitis. The tool can be used to prevent infection of the lungs by pneumocysts.
    • With cystitis and other infections of the excretory system.
    • With travelers' diarrhea, shigellosis, cholera, typhoid and some other gastrointestinal infections.
    • With brucellosis, toxoplasmosis, osteomyelitis, aktikomikoze and some other infections.

    Perhaps you will be interested to see the release of the program E. Komarovsky, which details infectious diseases of the urinary tract in children:

    At what age is it allowed to take?

    The use of Biseptol at the age of 1 year is possible. Such a drug in the form of a suspension is prescribed to children older than 2 months. If the mother has HIV infection, the use of medication in an infant is acceptable after 6 weeks of age. From the age of 3, not only the liquid form is allowed to be treated, but also tablets, but more often they are given to children over 6-7 years old when the child can safely swallow this solid form.

    Instructions for use and dosage

    The suspension is offered to children after meals and washed down with a sufficient amount of water. Single dose is determined by age:

    Children 2-5 months

    2.5 ml (120 mg of active compound)

    A child from six months to 5 years

    5 ml (240 mg of active ingredient)

    Children 6-12 years old

    10 ml (480 mg of active substance)

    A child over 12 years old

    20 ml (960 mg of active ingredient)

    The duration of Biseptal therapy depends on the pathology. For example, with shigellosis, the medicine is given for 5 days, with cystitis - from 10 to 14 days, with bronchitis - 2 weeks, and with typhoid fever, the treatment can be several months. As a rule, the remedy is not given for less than five days, and from the moment when the symptoms of the disease disappear, the therapy is continued for another 2 days.

    The drug is given twice at an interval of 12 hours. If the infection is severe, the doctor may increase the dosage by 50%.

    Interaction with other drugs and food

    • Biseptol has the ability to enhance the effect of treatment with indirect anticoagulants, methotrexate and hypoglycemic agents.
    • When combined with phenytoin, its therapeutic effect and toxicity increases.
    • The administration of Biseptol and diuretics increases the risk of reducing the number of platelets.
    • Biseptol reduces the effectiveness of certain antidepressants.
    • The drug should not be combined with drugs, which have a depressant effect on blood formation, as well as with naproxen and aspirin.
    • In the nutrition of the child during the treatment with Biseptol, it is advised to limit the dishes from cabbage, beans, carrots, tomato and peas, as well as fatty cheeses and other animal products.
    • Before taking the drug should not eat dried fruits and beet dishes, as well as pastries, because such products are very quickly digested.
    • The effect of Biseptol is partially neutralized with milk, therefore, it is impossible to take the medicine with this product.

    Biseptol tablets, instructions for use

    Adults take 960 mg once, or 480 mg in 2 divided doses. Severe infections: three times 480 mg. Course 1-2 weeks.

    With acute brucellosis The course of treatment is 3-4 weeks, paratyphoid and typhoid fever - up to 3 months.

    Chronic infections: twice 480 mg tablets.

    Biseptol children

    It is noted that the drug can be used from 3 months of life, and the doses will naturally vary. However, this should be done with caution and only as directed by the physician. In some countries of the world, Biseptol may be used for children only from the age of 12.

    Usually they can prescribe a suspension from 3 months, tablets - from 2 years.

    Instructions on Biseptol for children

    At the age of 3 to 6 months, 2.5 ml of syrup is prescribed 2 times a day. The interval between doses should be at least 12 hours. From six months to 3 years take up to 5 ml of Biseptol suspension for children twice a day.

    From 3 to 6 years, the dosage is made equal to 5-10 ml twice, 6-12 years - 10 ml 2 times a day. From the age of 12, take 20 ml every 12 hours.

    How to take pills for children?

    At the age of 2-5 years: 2 times 120 mg per 24 hours. From 6 to 12 years old, 480 mg is used every 12 hours.

    The course of treatment is 5-7 days. When using drugs for children should drink plenty of water.

    Analogs of Biseptol

    Analogs are drugs: Bakteptol, Bactrim, Biseptazole, Biseptrim, Groseptol, Co-Trimoxazole, Oriprim, Raseptol, Soluceptole, Sumetrolim, Triseptol.

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